负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗  

Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice

作　　者：王通 柳时[3] 张秀英[1] WANG Tong LIU Shi ZHANG Xiuying(Veterinary Pharmacology and Toxicology Laboratory, College of Veterinary Medicine ,Northeast Agricultural University,Harbin 150030, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China DaCheng Farm （Liaoning） Limited Company, Shenyang 110000, China)

机构地区：[1]东北农业大学兽医学院兽医药理学与毒理学实验室,哈尔滨150030 [2]辽宁大成农牧实业有限公司,沈阳110000 [3]中国科学院长春应用化学研究所,高分子物理和化学国家重点实验室,长春1300223

出　　处：《应用化学》2017年第10期1127-1133,共7页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(81602715)资助项目~~

摘　　要：为了探讨载有顺铂的温敏凝胶对小鼠宫颈癌的局部化疗作用,制备了载有顺铂的泊洛沙姆温敏凝胶,并通过流变学、体外溶蚀、体外释放等技术手段表征其结构和性能,采用鼠源宫颈癌U14细胞制备了原位宫颈/阴道癌模型,将载药凝胶灌注入荷瘤鼠阴道,评价载药凝胶对小鼠宫颈/阴道癌的抑制作用。结果表明,载有顺铂的泊洛沙姆温敏凝胶经阴道给药后对小鼠宫颈/阴道癌的抑瘤率可达到63.1%,可有效抑制小鼠宫颈癌的生长,而系统安全性则远远高于静脉注射顺铂。因此,载有顺铂的温敏凝胶有可能成为一种新型的宫颈癌治疗剂型。To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice, cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63. 1% by vaginal administration of cisplatin-loaded poloxamer hydrogel, which presents a new formulation for the local drug delivery v/a vagina against cervical cancer.

关 键 词：顺铂 温敏凝胶 宫颈癌 泊洛沙姆 

分 类 号：O633.1[理学—高分子化学]