医用可降解聚乳酸的化学修饰及其作为胆道支架的应用  

Chemical Modification of Medical Degradable Polylactic Acid and Its Application in Biliary Stent

作　　者：张亮[1] 马锋[2] 

机构地区：[1]西安交通大学医学院第一附属医院招标采供办公室,陕西西安710061 [2]西安交通大学先进外科技术与工程研究所,陕西西安710061

出　　处：《合成化学》2017年第10期832-835,共4页Chinese Journal of Synthetic Chemistry

基　　金：陕西省教育厅科研计划项目(2013JK0920)

摘　　要：乳酸纯化后合成聚乳酸(PLA);采用乙二醇对PLA端基进行化学修饰,合成了医用可降解端羟基聚乳酸(PLA-OH),其结构和性能经1H NMR,IR,GPC和TGA表征。通过3D打印技术,设计成型了PLA-OH胆道支架(1),并研究了1的降解行为。结果表明:处理温度为90℃,处理时间为40 min时,乳酸纯度达最大值99%;PLA-OH的Mw/Mn为1.3,分子量分布较窄;PLA-OH热稳定性较好,T5%为240℃;1降解性能良好,在PBS缓冲液中降解11 w,残余量为20.8%。Polylactic acid（PLA） was synthesized from purified lactic acid. Medical degradable poly- lactic acid with hydroxyl end group （PLA-OH） was obtained via chemical modification of end group in glycol. The structure and properties were characterized by 1H NMR, IR, GPC and TGA. PLA-OH bil- iary stent（ 1 ） was designed and prepared by 3D printing technology and the degradation behavior was observed. The results showed that purity of lactic acid was 99% when processing temperature and time were 90℃ and 40 rain, respectively. The Mw/Mn of PLA-OH was 1.3 and molecular weight distribu- tion was narrow. PLA-OH exhibited good thermal satability with T5% of 240℃. 1 demonstrated good degradability with residual volume of 20.8 % after degradating in PBS buffer solution for eleven weeks.

关 键 词：端羟基聚乳酸 化学修饰 合成 PLA-OH胆道支架 降解行为 

分 类 号：O63[理学—高分子化学] R783.1[理学—化学]