重组人脑利钠肽治疗急性心力衰竭的近期效果观察  

Short-term efficacy of recombinant human brain natriuretic peptide in acute heart failure

作　　者：骆志鹏[1] 黄海荣[1] 王天文[1] 

机构地区：[1]广东省化州市第二人民医院内科,广东化州525141

出　　处：《广东医科大学学报》2017年第1期36-38,共3页Journal of Guangdong Medical University

摘　　要：目的观察重组人脑利钠肽(rhBNP)治疗急性心力衰竭的近期效果。方法 60例急性心力衰竭患者随机分为观察组与对照组。两组均予以常规抗心衰治疗,观察组加用rhBNP治疗,对照组加用硝酸甘油治疗。对比两组近期疗效。结果观察组总有效率、左室射血分数明显高于对照组(P<0.01),而治疗后心率、血浆NT-proBNP水平低于对照组(P<0.01)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 rhBNP辅助治疗急性心力衰竭近期疗效显著,可有效降低血浆NT-proBNP水平。Objective To observe the short-term efficacy of recombinant human brain natriuretic peptide （rhBNP） in acute heart failure （AHF）. Methods Sixty AHF patients were randomly divided into observatiori and control groups. Based on the conventional therapy, rhBNP and nitroglycerin were added respectively in observation and control groups. The short-term efficacy was compared between two groups. Results Compared with control group, the overall effective rate and left ventricular ejection fraction （LVEF） were increased （P〈0.01）, but heart rate and plasma NT-proBNP levels were decreased in observation group （P〈0.01）. The incidence of adverse reactions showed no difference between two groups （P〉0.05）. Conclusion The rhBNP adjuvant treatment can possess a significantly short-term effect and reduce plasma NT-proBNP levels in AHF patients.

关 键 词：急性心力衰竭 脑利钠肽 疗效 

分 类 号：R541.6[医药卫生—心血管疾病]