抗SmD1抗体检测在系统性红斑狼疮中的应用价值  

Application of anti-SmD1 antibody in systemic lupus erythematosus diagnosis

作　　者：钱丽丽 宋献美 QIAN Li-li SONG Xian-mei(Henan Medical College, Zhengzhou, Henan 451191, China)

机构地区：[1]河南医学高等专科学校,河南郑州451191

出　　处：《热带医学杂志》2017年第9期1170-1173,共4页Journal of Tropical Medicine

摘　　要：目的分析抗SmD1抗体检测在系统性红斑狼疮(SLE)中的应用价值。方法检测143例SLE患者和105例非SLE患者的抗SmD1抗体(酶联免疫吸附试验)、抗ds DNA抗体(间接免疫荧光法)、Anu A和抗Sm抗体(殴蒙斑点法),分析抗SmD1抗体在SLE诊断中的价值、与患者疾病活动性的关系及抗SmD1抗体阳性SLE患者的临床特征。结果抗SmD1抗体在SLE诊断中的敏感性为68.53%,特异性为97.14%,敏感性明显高于其他自身抗体,差异有统计学意义(P<0.05),而诊断特异性比较,差异无统计学意义(P>0.05);抗SmD1抗体与SLE患者疾病活动性呈正相关(r=0.689,P=0.027);抗SmD1抗体阳性的SLE患者发热、关节炎、狼疮肾炎、血液系统异常及雷诺现象的发生率明显高于阴性组,差异有统计学意义(P<0.05)。结论抗SmD1抗体检测在SLE患者的诊断及疾病进程具有重要的参考价值。Objective To analyze the application value of anti-SmD1 antibody in systemic lupus erythematosus（SLE）diagnosis. Methods Anti SmD1 antibody（enzyme-linked immunosorbent assay）,anti ds DNA antibody（indirect immunofluorescence）,Anu A and anti Sm antibody（European spot method）were detected in 143 cases with SLE and 105 cases with non-SLE. The value of anti-SmD1 antibody in the diagnosis of SLE,its relationship with the disease activity and clinical characteristics of anti SmD1 antibody positive patients were analyzed. Results Using anti SmD1 antibody for the diagnosis of SLE had a sensitivity of 68.53% and specificity of 97.14%;the sensitivity was significantly higher than using other autoantibodies（P〈0.05）,but there was no significant difference in the diagnostic specificity（P〉0.05）. Anti SmD1 antibody was positively correlated with disease activity in patients with SLE（r=0.689,P=0.027）. The incidences of fever,arthritis,lupus nephritis,abnormal blood system and Reynolds phenomenon of the anti-SmD1 positive SLE patients were significantly higher those of the anti-SmD1 negative SLE patients（P〈0.05）. Conclusion Anti-SmD1 antibody detection in patients with SLE has an important reference value.

关 键 词：抗SMD1抗体 系统性红斑狼疮 应用价值 

分 类 号：R593.241[医药卫生—内科学]