老年AECOPD患者呼吸系统病毒感染的临床特征  

Clinical characteristics of respiratory viral infection in elderly patients with AECOPD

作　　者：李涛[1] 刘向群[1] 刘景双 LI Tao LIU Xiang-qun LIU Jing-shuang(Department of Respiration, the First People＇s Hospital of Xuzhou, Xuzhou, Jiangsu 221002, China)

机构地区：[1]徐州市第一人民医院呼吸科,江苏徐州221002

出　　处：《热带医学杂志》2017年第9期1206-1209,共4页Journal of Tropical Medicine

摘　　要：目的观察老年慢性阻塞性肺疾病急性加重期(AECOPD)患者呼吸系统病毒感染的临床特征,为临床防治老年AECOPD疾病提供参考依据。方法选取2013年4月至2016年7月期间徐州市第一人民医院收治的老年AECOPD患者97例为研究对象,使用反转录-聚合酶链式反应(RT-PCR)方法检测是否病毒感染,根据结果将患者分成阳性组(n=35)和阴性组(n=62),分析患者的临床特征和呼吸系统病毒感染的关系。结果 97例患者中35例患者的病毒检测结果为阳性,阳性率为36.08%,鼻病毒hRV的检出率为最高;Logistic回归分析结果表明,合并吸烟、呼吸衰竭和糖尿病是患者发生病毒感染的独立影响因素,差异有统计学意义(P<0.05);阳性组患者的胸痛发生情况显著高于阴性组,差异有统计学意义(P<0.05),其他临床表现和生化检查结果差异均无统计学意义(P>0.05)。结论老年AECOPD患者的病毒检测率最高的是h RV病毒,吸烟、呼吸衰竭和糖尿病使患者病毒感染的风险增加,但患者无特异性临床表现。Objective To observe the virus infection status of respiratory system in elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,and to analyze its clinical characteristics in order to provide referencefor prevention and treatment of elderly AECOPD disease. Methods 97 patients with AECOPD in our hospital from April2013 to July 2016 were selected as the subjects. Reverse transcription polymerase chain reaction（RT-PCR） methodwas used to detect virus infection;according to the results,the patients were divided into positive group（n=35）andnegative group（n=62）. The clinical characteristics and the relationship between respiratory virus infection were analyzed.Results Among 97 patients,there were 35 cases positive for virus detection,with a positive rate of 36.08% and thedetection rate of rhinovirus h RV was the highest among the 35 patients. Logistic regression analysis showed that smoking,respiratory failure and diabetes were the independent influencing factors of viral infection（P〈0.05）. The incidence of chestpain in the positive group was significantly higher than that in the negative group（P〈0.05）. There was no significantdifference between the other clinical manifestations and biochemical test results. Conclusion The highest rate of virusdetection in elderly patients with AECOPD was h RV virus;smoking,respiratory failure and diabetes could increase the risksof viral infection in patients,but patients do not have specific clinical manifestations.

关 键 词：老年患者 AECOPD 病毒感染 

分 类 号：R563[医药卫生—呼吸系统]