短信干预对2型糖尿病患者糖化血红蛋白和血糖水平影响的Meta分析  

Effects of short message intervention on glycosylated hemoglobin and blood glucose levels on patients with type 2 diabetes mellitus: a meta-analysis

作　　者：潘佳雪 李亚男[1,2] 郁娟[1] 张旭[1] 田金徽[2,3] 韩雪梅[1] 

机构地区：[1]兰州大学公共卫生学院,兰州730000 [2]兰州大学循证医学中心,兰州730000 [3]甘肃省循证医学与临床转化重点实验室,兰州730000

出　　处：《中国循证医学杂志》2017年第10期1158-1166,共9页Chinese Journal of Evidence-based Medicine

基　　金：2015年甘肃省自然科学基金项目(编号:1506RJZA229);2015年兰州市科技计划项目(编号:2015-2-52);兰州大学中央高校基本科研业务专项资金资助(编号:lzujbky-2015-233)

摘　　要：目的系统评价短信干预对2型糖尿病患者的糖化血红蛋白(HbA1c)和血糖水平的影响。方法计算机检索PubMed、EMbase、The Cochrane Library、CNKI和CBM数据库,搜集短信干预2型糖尿病的随机对照试验(RCT),检索时限均从建库至2016年8月。由2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Stata 12.0软件进行统计分析。结果共纳入17个RCT,包括2 879例患者。Meta分析结果显示:在常规治疗基础上,短信干预可降低2型糖尿病患者的HbA1c水平[3个月:SMD=–0.50,95%CI(–0.67,–0.34),P<0.001;6个月:SMD=–0.33,95%CI(–0.59,–0.07),P=0.012]、FBG水平[3个月:SMD=–0.28,95%CI(–0.45,–0.11),P=0.001;9个月:SMD=–0.99,95%CI(–1.44,–0.54),P<0.001]和PBG水平[3个月:SMD=–0.99,95%CI(–1.54,–0.44),P<0.001;6个月:SMD=–0.81,95%CI(–1.25,–0.36),P<0.001;9个月:SMD=–0.78,95%CI(–1.23,–0.34)]。结论现有证据表明,短信干预能够对2型糖尿病患者产生一定的干预效应,具有改善HbA1c和血糖水平的作用。但受纳入研究数量和质量的限制,上述结论尚需展开更多高质量的研究予以验证。Objective To systematically review the effects of short message intervention on glycosylated hemoglobin （HbAlc） and blood glucose levels on patients with type 2 diabetes mellitus. Methods We electronically searched databases including PubMed, EMbase, The Cochrane Library, CNKI and CBM from inception to August 2016, to collect randomized controlled trails （RCTs） about short message intervention in type 2 diabetes mellitus patients. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Then metaanalysis was performed using Stata 12.0 software. Results A total of 17 RCTs involving 2 879 patients were included. The results of meta-analysis showed that, on the basis of basic treatment, the use of text messages could lower the levels of HbAlc （SMD3months=-0.50, 95%CI -0.67 to -0.34, P〈0.001; SMD6months=-0.33, 95%CI -0.59 to -0.07, P=0.012）, FBG （SMD3months= -0.28, 95%CI -0.45 to -0.11, P=0.001; SMD9 months=-0.99, 95%CI -1.44 to -0.54, P〈0.001）, PBG （SMD3months=-0.99, 95%CI -1.54 to -0.44, P〈0.001; SMD6months=-0.81, 95%CI --1.25 to -0.36, P〈0.001; SMD9months=-0.78, 95%CI -1.23 to -0.34, P=0.001）. Conclusion The current evidence shows that the use of SMS can improve glycosylated hemoglobin and blood glucose levels on type 2 diabetes patients. Due to limited quality and quantity of the included studies, the above conclusions are needed to be verified by more high quality studies.

关 键 词：短信 2型糖尿病 随机对照试验 META分析 系统评价 

分 类 号：R587.1[医药卫生—内分泌]