苯并噻唑基荧光探针的设计、合成与应用研究进展  

Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes

作　　者：蒋凯[1] 曹梁[1] 郝志峰[2] 陈美燕 程洁銮 李晓 肖萍 陈亮 汪朝阳[1] Jiang Kai Cao Lianga Hao Zhifeng Chen Meiyana Cheng Jieluan Li Xiao Xiao Ping Chen Lianga Wang Zhaoyang(School of Chemistry and Environment, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, South ChinaNormal University, Guangzhou 510006 School of Chemical Engineering and Light Industry, Cruangdong University of Technology, Guangzhou 510006)

机构地区：[1]华南师范大学化学与环境学院教育部环境理论化学重点实验室,广州510006 [2]广东工业大学轻工化工学院,广州510006

出　　处：《有机化学》2017年第9期2221-2236,共16页Chinese Journal of Organic Chemistry

基　　金：广州市科技计划科学研究专项(No.201607010251);广东省应用型科技研发专项资金(No.2016B090930004);华南师范大学大创计划(No.20161415);广东省自然科学基金(No.2014A030313429);广东省科技计划(No.2017A010103016)资助项目~~

摘　　要：苯并噻唑基团具有特征荧光,且结构中含有N和S杂原子,因而在荧光探针结构中常被视为荧光基团与识别基团,承担荧光信号输出与提供结合位点的重要作用.利用苯并噻唑基团的特点来设计合成性能更佳的荧光探针已逐渐成为荧光探针研究领域中瞩目的焦点.对近几年来报道的苯并噻唑基荧光探针按不同的检测对象分为金属阳离子、阴离子、含硫化合物及其它物种等四大类,综述了其设计、合成、作用机理及其相关检测应用,并展望了其未来的发展趋势.Benzothiazole group is of characteristic fluorescence, and each also contains two heteroatoms（N and S）. Hence, benzothiazole group is always viewed as fluorophore and recognition moiety in structure of fluorescent probes, playing an essential role on provision of fluorescence signal and binding sites. Recently, utilizing these properties of benzothiazole moiety to design and synthesize better fluorescent probes has gradually become one of focuses in fluorescent detection research. Classifying benzothiazole-based fluorescent probes into four main categories according to different analytes, such as metal cations, anions, sulfur-containing compounds and other species, the design, synthesis, detecting mechanism and relevant application of these probes are reviewed. And their development tendency in the future is prospected.

关 键 词：苯并噻唑 荧光探针 设计与合成 检测应用 进展 

分 类 号：O626.25[理学—有机化学] O657.3[理学—化学]