官能团导向的C—H键与有机金属试剂构建C—C键的偶联反应  

Cross-Coupling of Directed C—H and Organometallic Reagents for C—C Bond Formation

作　　者：李桦 任相伟 赵温涛[1] 唐向阳[1] 王光伟[1,2] LI Hu Ren Xiangweia Zhao Wentaoa Tang Xiangyang Wang Guangwei(Department of Chemistry, School of Science, Tianjin University, Tianjin 300350 anfln Key Laboratory of Molecular Optoelectyonic Science, Tianjin 300072)

机构地区：[1]天津大学理学院化学系,天津300350 [2]天津市分子光电科学重点实验室,天津300072

出　　处：《有机化学》2017年第9期2287-2302,共16页Chinese Journal of Organic Chemistry

基　　金：国家重点基础研究发展计划(No.2015CB856500);天津市自然科学基金(No.16JCYBJC20100)资助项目~~

摘　　要：过渡金属催化的碳氢键活化是有机化学领域的研究热点之一,碳氢键直接参与的偶联反应为碳碳键的构建提供了的一种高效便捷途径.过渡金属活化碳氢键产生的碳-金属中间体与有机亲电试剂的偶联反应已有广泛报道和综述,相应的中间体与有机金属试剂的氧化偶联反应在近年来不断有新的研究成果出现.该综述以C—H及C—M中的碳原子的杂化类型作为分类标准,对近十年来不同类型的碳氢键与有机金属试剂的偶联反应进行总结和讨论,并对今后的发展方向进行展望.Transition metal-catalyzed C—H activation is one of the most important areas in organic synthesis. Directed C—H activation can obviate the prefunctionalization of substrate, therefore providing a highly efficient and concise strategy for C—C formation. The cross-coupling of transition metal-activated C—H bond with organic electrophilic reagents has been proven effective for construction of various C—C bonds. Meanwhile, the oxidative coupling between the corresponding intermediates with organometallic reagents has become the focus for chemists due to their high reactivity, and notable achievements have been made in recent years. Here the oxidative couplings of C—H bond and organometallic reagents have been discussed and summarized according to the hybridization of substrate and organometallic reagents.

关 键 词：C—H键活化 过渡金属催化 导向基团 有机金属试剂 碳碳键的形成 

分 类 号：O621.251[理学—有机化学]