外泌体在骨代谢中的作用  

Role of exosomes in bone metabolism

作　　者：符灵芝 刘鸿飞[2] 谢芬[1] 戴如春[1] Fu Lingzhi Liu Hongfei Xie Fen Dai Ruchun.(The Second Xiangya Hospital of Central South University, Institute of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Changsha 410011, China Department of Endocrinology and Metabolism, The Third People＇s Hospital of Cheazhou, Chenzhou 423000, China)

机构地区：[1]中南大学湘雅二医院、代谢内分泌研究所、国家代谢性疾病临床医学研究中心,长沙410011 [2]郴州市第三人民医院内分泌科,423000

出　　处：《国际内分泌代谢杂志》2017年第5期316-320,共5页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81670804,81270960）;教育部“新世纪优秀人才支持计划”（NCET-11-0507）;中华国际医学交流基金会（医基发[2014]14号）;中南大学（中大医字[2013]15号-86）

摘　　要：外泌体是多种细胞在生理或病理状态下主动分泌到细胞外的纳米级囊泡,富含蛋白质、核酸、脂质等生物活性物质,参与细胞间信息交流与传递.目前已有研究表明,外泌体能通过信号蛋白、miRNAs等调控成骨细胞、破骨细胞及骨髓间充质干细胞的增殖、分化,介导骨生成和骨吸收过程,在多种骨代谢疾病的发生、发展中起重要作用.Exosomes are nanoscale membrane vesicles that are proactively released by various cell types into the extracellular microenvironment on physiological or pathological conditions, their components are heavily enriched in the bioactive proteins, nucleic acid, lipids etc., with the function of intercellular information communication and transfer.Recently research demonstrated that exosomes could regulate proliferation and differentiation of osteoblasts, osteoclasts, bone marrow mesenchymal stem cells through signaling proteins and miRNAs, mediate bone formation and bone resorption, and play important roles in the occurrence and development of various bone metabolic diseases.

关 键 词：外泌体 成骨细胞 破骨细胞 骨髓间充质干细胞 骨代谢疾病 

分 类 号：R681[医药卫生—骨科学]