体质量水平对行激素治疗哮喘预测指数阳性喘息患儿症状缓解率、急性发作率及再住院率的影响  

Influence of body weight on symptom remission rate, acute attack rate and re-hospitalization rate in children of asthma with API positive treated by hormone therapy

作　　者：钱玲鹤[1] Qian Linghe(Department of Pediatrics, the Second People＇s Hospital of Yuhang District of Hangzhou City, Hangzhou 311121, China)

机构地区：[1]杭州市余杭区第二人民医院儿科,311121

出　　处：《中国医师进修杂志》2017年第8期745-748,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨体质量水平对行激素治疗哮喘预测指数（API）阳性喘息患儿症状缓解率、急性发作率及再住院率的影响.方法 研究对象选取2014年3月至2016年3月收治API阳性喘息患儿共120例,根据Kaup指数常模肥胖界值分为正常组（63例）和肥胖组（57例）,均给予常规药物治疗;比较两组患儿症状缓解率、随访急性发作率、急诊就医率及再住院率等.结果 正常组患儿治疗后2周和4周症状缓解率为52.38%（33/63）、90.48%（57/63）;肥胖组患儿治疗后2周和4周症状缓解率为35.09%（20/57）、77.19%（44/57）;肥胖组患儿症状缓解率显著低于正常组（P〈0.05）;正常组患儿随访3个月和6个月急性发作率为19.05%（12/63）、9.52%（6/63）;肥胖组患儿随访3个月和6个月急性发作率为31.58%（18/57）、19.30%（11/57）;肥胖组患儿随访急性发作率显著高于正常组（P〈0.05）;同时正常组患儿急诊就医率和再住院率为6.35%（4/63）、3.17%（2/63）;肥胖组患儿急诊就医率和再住院率为19.30%（11/57）、15.79%（9/57）;肥胖组患儿急诊就医率和再住院率均显著高于正常组（P〈0.05）.结论 肥胖可导致行激素治疗API阳性喘息患儿症状缓解效果下降,急性发作率和再住院率上升,不利于临床预后改善;而控制体质量水平有助于提高患儿激素治疗敏感性.Objective To investigate the influence of body weight on symptom remission rate, acute attack rate and re-hospitalization rate in children of asthma with API positive treated by hormone therapy. Methods All of 120 children of asthma with API positive treated by hormone therapy were chosen in the period form March 2014 to March 2016 and divided by Kaup index into conventional group （63 patients） and obesity group （57 patients）; and the symptom remission rate, the acute attack rate in follow-up, the emergency medical treatment rate and the re-hospitalization rate of both groups was compared. Results The symptom remission rate 2 and 4 weeks after treatment in conventional group was 52.38%（33/63） and 90.48%（57/63） respectively. The symptom remission rate 2 and 4 weeks after treatment in obesity group was 35.09%（20/57） and 77.19%（44/57） respectively. The symptom remission rate of obesity group was significantly lower than that of conventional group （P〈0.05）. The acute attack rate in the follow-up of the 3rd and 6th months in conventional group was respectively 19.05%（12/63） and 9.52%（6/63）. The acute attack rate in the follow-up of the 3rd and 6th months in obesity group was respectively 31.58%（18/57） and 19.30%（11/57）. The acute attack rate in the follow-up of obesity group was significantly higher than that in conventional group （P〈0.05）. The emergency medical treatment rate and the re-hospitalization rat of conventional group was respectively 6.34%（4/63） and 3.17%（2/63）. The emergency medical treatment rate and the re-hospitalization rat of obesity group was separately 19.30%（11/57） and 15.79%（9/57）. The emergency medical treatment rate and the re-hospitalization rat of obesity group was significantly higher than that of conventional group （P 〈0.05）. Conclusions Obesity can decrease symptom remission effects and increase acute attack rate and re-hospitalization rate in children of asthma with API positive treated by hormone therapy.Body weigh

关 键 词：体质量 激素类 喘息 疗效 

分 类 号：R725.6[医药卫生—儿科]