2015-2016年保定市手足口病伴脱甲症病例流行病学特征分析  

Epidemiological characteristics of hand-foot-mouth disease complicated with onychomadesis in Baoding City,2015-2016

作　　者：李娟娟[1] 王玉肖[2] 周美静[1] 赵灿[3] 苏明[1] 陈妍[1] 郑丽伟[1] 王辉[1] 张亮[1] 倪祥文[1] 

机构地区：[1]保定市疾病预防控制中心,河北保定071000 [2]唐县人民医院 [3]保定市第一中医院

出　　处：《实用预防医学》2017年第11期1318-1320,共3页Practical Preventive Medicine

基　　金：保定市科学技术研究与发展指导计划项目(项目编号:15ZF088)

摘　　要：目的对保定市手足口病伴脱甲症的病例进行流行病学特征分析,为制定防控措施提供科学依据。方法对保定市2015年1月-2016年5月手足口病确诊病例进行随访,从发病后连续观察3个月,筛选脱甲病例并对其流行病学特征进行分析。分类资料利用SPSS 11.5软件进行卡方检验。结果在684份肠道病毒检测阳性的手足口病确诊病例中143例出现了脱甲症状,脱甲发生率为20.91%。脱甲发生与手足口病患者的年龄、性别、城乡分布以及发病月份无关,但北部和中部脱甲发生率(25.12%、22.87%)显著高于南部(14.22%,P<0.05)。肠道病毒EV71(EV71)、柯萨奇病毒A16型(Cox A16)、柯萨奇病毒A6(CoxA6)以及其他肠道病毒所致的手足口病均出现脱甲现象,其中以CoxA6型手足口病脱甲发生率最高,为44.64%。结论 2015-2016年保定市脱甲症病例集中在北部和中部,CoxA6为主要病原。Objective To analyze the epidemiological characteristics of hand-foot-mouth disease （HFMD） complicated with onychomadesis in Baoding City so as to provide a scientific basis for developing prevention and control strategies. Methods The cases of HFMD diagnosed in Baoding City from January 2015 to May 2016 were continuously followed up for 3 months after the onset of the disease. The cases with onychomadesis were screened, and then their epidemiological characteristics were analyzed. The categorical data were analyzed by chi-square test using SPSS 11.5 software. Results Among the 684 enterovirus-positive HFMD cases, 143 cases developed onychomadesis, with the incidence being 20.91%. The occurrence of onyehomadesis was unre- lated to the patients＇ age, gender, urban or rural distribution and onset month, but the incidence rates of onyehomadesis in the north and central areas （25.12%, 22.87%） were significantly higher than that in the south area （ 14.22%, P〈0.05）. Onyeho- madesis occurred in the HFMD cases induced by enterovirus 71 （EVT1） , coxsackie enterovirus （COX） A16, COXA6 and other enteroviruses, of which the incidence rate of onychomadesis in the HFMD caused by COXA6 was the highest （ 44.64% ）. Conclusions Most of the onychomadesis cases occur in the north and central areas of Baoding City in 2015-2016, and COXA6 is the main pathogen.

关 键 词：手足口病 脱甲症 流行病学 柯萨奇肠道病毒A6 

分 类 号：R512.5[医药卫生—内科学]