乙烯聚集诱导发光探针在生物成像和药物递送中的应用研究进展  

Research progress on aggregation induced emission probes with tetraphenylethene structure for biological imaging and drug delivery

作　　者：苏姗 马宇帆 田立枚 王卓 Shan Su Yufan Ma Limei Tian Zhuo Wang(State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China)

机构地区：[1]北京化工大学理学院,化工资源有效利用国家重点实验室,北京软物质科学与工程高精尖创新中心,北京100029 [2]湖南大学化学化工学院,化学生物传感与计量学国家重点实验室,长沙410082

出　　处：《中国科学：化学》2017年第9期1075-1084,共10页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21575032);中央高校科研业务费(编号:buctrc201607,PYBZ1707);湖南大学化学生物传感与计量学国家重点实验室开发课题;北京分子科学国家实验室开发课题资助项目

摘　　要：基于聚集诱导发光(AIE)机制的生物传感器具有灵敏度高、高量子产率、便于合成等优点,所以具有AIE特性的有机小分子得到了科研工作者的广泛关注.随着对AIE分子结构和理论知识的深入认识,针对细胞或微生物结构特点设计合成的可与细胞或微生物特异性结合的有机荧光分子,可准确、便捷、有效地实现对细胞或微生物的成像和靶向药物递送,对扩展有机分子探针的生物应用具有重要的推动作用.本文将重点阐述近几年具有AIE特性的四苯乙烯衍生物荧光分子在细胞和微生物识别成像,靶向递送和抗菌性能方面的应用,为后续研究工作提供借鉴和指导.Aggregation-induced emission （AIE） probes show high sensitivity, high quantum yield and can be synthesized conveniently. Organic molecules with AIE characteristics have attracted much attention from scientists. With the exploration of molecular structure and theoretical knowledge of AIEs, the developed probes can image cells and microbes selectivity, and deliver drugs effectively, which has an important role in promoting the biological application of organic molecular probes. In this review, we focus on the application of tetraphenylethylene derivatives with AlE characteristics in cell and microbial recognition imaging, targeted delivery and antibacterial properties in recent years, and provide references for the follow-up research work.

关 键 词：聚集诱导发光 探针 生物成像 药物递送 抗菌 

分 类 号：O657.3[理学—分析化学]