盐酸多奈哌齐片联合氯氮平分散片治疗阿尔茨海默病伴行为障碍的临床研究  

Clinical trial of donepezil hydrochloride tablets combined with clozapine dispersible tablets in the treatment of elderly Alzheimer's disease with behavioral disorder

作　　者：周勇 龙明 冉宏 

机构地区：[1]重庆三峡医药高等专科学校附属医院神经内科,重庆万州404000

出　　处：《中国临床药理学杂志》2017年第19期1897-1899,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81100948)

摘　　要：目的观察盐酸多奈哌齐片联合氯氮平分散片治疗阿尔茨海默病伴行为障碍的临床疗效及安全性。方法将80例阿尔茨海默病伴行为障碍患者随机分为对照组40例和试验组40例。对照组予以盐酸多奈哌齐5 mg,服用1个月后可增至10 mg,qd,晚上睡前口服;试验组在对照组治疗的基础上,予以氯氮平起始剂量25 mg,在前2~3周内缓慢加量,每4~5天增加25~50 mg,直到200mg·d^(-1),晚上睡前口服。2组患者均治疗6个月。比较2组患者的临床疗效、阿尔茨海默病行为病理评定量表(BEHAVE-AD)评分,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为87.50%(35/40例)和55.00%(22/40例),BEHAVE-AD评分分别为(4.44±1.95)和(8.86±2.47)分,差异均有统计学意义(均P<0.05)。2组患者的药物不良反应主要有恶心、口干、头晕、嗜睡、体重增加和便秘,且试验组和对照组的药物不良反应发生率分别为40.00%和37.50%,差异无统计学意义(P>0.05)。结论盐酸多奈哌齐片联合氯氮平分散片治疗阿尔茨海默病伴行为障碍的临床疗效确切,且不增加药物不良反应的发生率。Objective To observe the clinical efficacy and safety of donepezil hydrochloride tablets combined with clozapine dispersible tablets in the treatment of elderly Alzheimer ＇s disease with behavioral disorder. Methods A total of 80 elderly patients with Alzheimer＇ s behavioral disorder were randomly divided into control group and treatment group with 40 cases per group. Control group was treated with donepezil hydrochloride tablet 5 mg and increased to 10 mg after 1month,qd,oral before bedtime. Treatment group was given clozapine dispersible tablet25 mg for the first dose with a rate of 25-50 mg at 4-5 days within the2-3 weeks up to 200 mg·d^-1,qd,oral before bedtime,on the basis of control group. Two groups were treated for 6 months. The clinical efficacy,Alzheimer＇s disease behavior rating scale（ BEHAVE-AD） score and adverse drug reactions were compared between two groups. Results After treatment,the total effective rates in treatment and control groups were 87. 5%（ 35/40 cases） and 55. 0%（ 22/40 cases）; BEHAVE-AD scores in treatment and control groups were（ 4. 44 ± 1. 95） and（ 8. 86 ± 2. 47） points, there were statistically significant differences（ all P〈0. 05）. The adverse drug reactions in two groups were based on nausea,dry mouth,dizziness,drowsiness,weight gain and constipation. The incidences of adverse drug reactions in treatment and control groups were 40. 00%and 37. 50% without significant difference（ P〉0. 05）. Conclusion Donepezil hydrochloride tablets combined with clozapine dispersible tablets have a definitive clinical in the treatment of elderly Alzheimer＇s disease with behavioral disorder,without increasing the incidence of adverse drug reactions.

关 键 词：盐酸多奈哌齐片 氯氮平分散片 阿尔茨海默病 行为障碍 安全性 

分 类 号：R971[医药卫生—药品]