血清丙氨酸氨基转移酶、谷氨酰转肽酶、铁蛋白、丙型肝炎病毒核糖核酸定量对聚乙二醇干扰素抗病毒疗效的影响  

Influence of serum ALT,GGT,ferritin and HCV-RNA on the antiviral effect of peginterferon

作　　者：游春芳[1] 周利民[1] 邓薇[1] 

机构地区：[1]四川省自贡市第一人民医院感染科,643000

出　　处：《临床合理用药杂志》2017年第27期20-22,24,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨血清丙氨酸氨基转移酶(ALT)、谷氨酰转肽酶(GGT)、血清铁蛋白(SF)、丙型肝炎病毒核糖核酸(HCV-RNA)定量对聚乙二醇干扰素抗病毒疗效的影响。方法选取四川省自贡市第一人民医院2014年1—6月收治的慢性丙型病毒性肝炎患者51例,以ALT值达100 IU/L、GGT值达50 IU/L、SF值达400 ng/ml、HCV-RNA定量达106copies/ml为界将患者分为低ALT、GGT、SF、HCV-RNA组与高ALT、GGT、SF、HCV-RNA组,均给予聚乙二醇干扰素a-2a联合利巴韦林治疗48周,随访24周。在0周时检测血清ALT、GGT、SF、HCV-RNA,在4、12、48及72周检测HCV-RNA以判断疗效。结果聚乙二醇干扰素抗病毒治疗前低GGT、SF、HCV-RNA组较高GGT、SF、HCV-RNA组能获得更好的持续病毒应签(SVR)(P<0.05),而ALT水平与疗效无相关性(P>0.05)。结论慢性丙型病毒性肝炎患者治疗前GGT、SF、HCV-RNA水平与聚乙二醇干扰素的疗效密切相关,提示GGT、SF、HCV-RNA的水平可较准确地预测慢性丙型病毒性肝炎患者聚乙二醇干扰素抗病毒治疗的疗效。Objective To study the influence of serum ALT,GGT,SF and HCV-RNA on the antiviral effect of peginterferon. Methods A total of 51 cases of 51 cases of chronic hepatitis C patients were selected from January to June 2014 in the First Hospital of Zigong,which were divided into high ALT（ ≥100 IU/L）,GGT（ ≥50 IU/L）,SF（ ≥400 ng/ml）,HCV-RNA（ ≥106copies/ml） group and low ALT（〈 100 IU/L）,GGT（〈 50 IU/L）,SF（ 〈400 ng/ml）,HCV-RNA（ 〈106copies/ml） group. Both groups were treated with peginterferon alfa-2a with ribavirin for 48 weeks,followed-up for 24 weeks. The levels of serum ALT,GGT,SF and HCV-RNA levels were determined at 0 week,and the serum HCV-RNA levels were determined at 4,12,48,72 weeks to judge the clinical effect. Results Before treatment,the SVR of low GGT,SF,HCV-RNA group were significantly higher than that of high GGT,SF,HCV-RNA group（ P 〈0. 05）,but there were no correlation between therapeutic effect and ALT levels（ P〉 0. 05）. Conclusion The levels of GGT,SF and HCV-RNA in chronic hepatitis C patients are closely related to the antiviral effect of peginterferon,which proves that the levels of serum GGT,SF and HCV-RNA can accurately predict the curative effect of peginterferon in treating chronic hepatitis C.

关 键 词：丙型肝炎 丙氨酸氨基转移酶 谷氨酰转肽酶 铁蛋白 丙型肝炎病毒核糖核酸 聚乙二醇干扰素Α-2A 

分 类 号：R512.63[医药卫生—内科学]