影响单囊胚移植临床妊娠及活婴出生的相关因素分析  

Factors Affecting the Clinical Pregnancy and Live Birth Following Single Blastocyst Transfer

作　　者：孙青 熊风 李观贵 万才云 陈培林 曾勇 

机构地区：[1]深圳中山泌尿外科医院生殖中心深圳市围着床期生殖免疫重点实验室深圳中山生殖与遗传研究所,518045

出　　处：《国际生殖健康／计划生育杂志》2017年第5期430-433,共4页Journal of International Reproductive Health/Family Planning

基　　金：深圳市科创委基础研究项目(JCYJ20160427113514229);深圳市科创委基础研究学科布局(JCYJ20160427113153295)

摘　　要：欧洲人类生殖与胚胎协会在2002年对辅助生殖技术(assisted reproductive technology,ART)治疗效果提出了准确定义的衡量标准,即单个健康婴儿的出生。减少ART治疗中出现的严重并发症——多胎妊娠最有效的措施就是进行单囊胚移植(single blastocyst transfer,SBT)。从理论上讲,SBT可以杜绝双卵双胎的发生,但是无选择地对所有患者采取SBT策略,则可能会导致妊娠率和活产率降低,给患者带来更高的经济和时间成本以及精神压力。所以,对合适的患者进行选择性单囊胚移植(elective single blastocyst transfer,e SBT)有利于提高该部分患者的临床妊娠率及活婴出生率。分析影响SBT临床妊娠结局及活婴出生的相关因素,评估患者自身条件及预测SBT的成功概率,从而使患者更容易接受SBT,最终使其获得健康婴儿的出生。European Society of Human Reproduction and Embryology（ESHRE） proposed the standard definition of the effective treatment with assisted reproductive technology（ART） in 2002： live birth and a single healthy baby. The best way to reduce multiple pregnancies, which is one of the serious complications of ART, is the strategy of single blastocyst transfer（SBT）. Theoretically, SBT can avoid the possibility of dizygotic twins.However, the SBT without any selection in patient and embryo may result in the reduction of pregnancy rate and live birth rate, but also increase economic and time cost as well as mental pressure. Therefore, the selective single blastocyst transfer（e SBT） should be recommended in those suitable patients. The consultation with respect to the factors related with the clinical outcome and live birth of SBT may be helpful to evaluate effectively the patients′status and the success rate of SBT, so as to accept SBT more easily, which eventually help them bring a healthy baby home as soon as possible.

关 键 词：胚胎移植 胚泡内细胞团 滋养层 妊娠率 出生率 治疗 

分 类 号：R714.8[医药卫生—妇产科学]