黄连素和二甲双胍二联用药治疗二型糖尿病的Meta分析  

Meta Analysis of Duplex Medication for Treatment of Type II Diabetes by Using Berberine and Metformin

作　　者：时政[1] 刘月[1] 王姗[1] 雨田[1] 

机构地区：[1]成都大学医学院,四川成都610106

出　　处：《成都大学学报（自然科学版）》2017年第3期238-242,268,共6页Journal of Chengdu University（Natural Science Edition）

基　　金：四川省科技厅科技支撑计划(2016NZ0060)资助项目

摘　　要：系统评价黄连素和二甲双胍二联用药治疗二型糖尿病的疗效.计算机检索Pub Med、Cochrane图书馆、EMbase、CNKI、CBMdisc、万方数据库,用Rev Man 5.1软件进行统计分析.共纳入12篇随机对照实验,合计包括共864例患者,其中治疗组387例,对照组477例.在降低FBG、PBG、LDL-C、Hb Alc、TC、TG方面和升高HDL-C方面,黄连素和二甲双胍二联用药作用优于单用二甲双胍,黄连素和二甲双胍二联用药治疗二型糖尿病及其并发症有好的疗效.但本结论尚需更多大样本、多中心,并设计严格的高质量RCT加以验证.The paper systematically evaluates the efficacy of berberine combined with metformin in the treatment of type II diabetes. Computer retrieval is adopted in Pub Med,the Cochrane library,EM base,CNKI,CBM disc and Wanfang database,and the Rev Man 5. 1 software is used for analysis. 12 randomly controlled trials with 864 patients( treatment group 387 cases and control group 477 cases)are included in the study. In terms of reducing LDL-C,FBG,PBG,Hb Alc,TC,TG and increasing HDL-C,the efficacy of the combined berberine and metformin is better than that of metformin in the treatment of type II diabetes. The conclusion drawn from the study is that the therapy of combining berberine and metformin shows efficacy in the treatment of type II diabetes,and meanwhile,more high-quality,multi-center and strictly designed RCTs are needed in the further study.

关 键 词：黄连素 二甲双胍 二型糖尿病 随机对照实验 META分析 

分 类 号：R587.1[医药卫生—内分泌]