中药汤剂预防抗结核药致药物性肝炎效果研究  

Study on the Effect of Traditional Chinese Medicine Decoction on Preventing Drug-induced Hepatitis in Anti-tuberculosis Drugs

作　　者：张志杰[1] 

机构地区：[1]郑州市第六人民医院,河南郑州450000

出　　处：《现代诊断与治疗》2017年第16期2944-2946,共3页Modern Diagnosis and Treatment

摘　　要：目的研究中药汤剂预防抗结核药致药物性肝炎效果。方法将2014年7月~2017年4月来院100例患者分为两组后接受不同的治疗。将两组患者治疗后GPT、TBAL及肝炎临床症状进行统计并分析。结果对照组患者GPT为(42.3±2.8)U/L,观察组患者GPT为(38.5±2.6)U/L。经分析,具统计学意义(t=7.03,P<0.01)。对照组患者TBAL为(22.4±3.1)μmol/L,观察组患者TBAL为(18.2±2.7)μmol/L。经分析,具统计学意义(t=7.22,P<0.01)。对照组出现黄疸、肋痛、恶心、乏力等症状的患者数均多于观察组,经统计学分析,均具有临床意义(P<0.01)。结论中药汤剂能有效预防抗结核病用药患者肝功能,预防黄疸、肋痛、恶心、乏力等肝炎导致的临床症状。有利于降低抗结核药物对肝脏损伤及维持抗结核药物正常应用。该治疗方法在临床上值得推广。Objective To study the effect of traditional Chinese medicine decoction on preventing druginduced hepatitis in anti-tuberculosis drugs.Methods From July 2014 to April 2017,100 patients were divided into two groups and received different treatments.The clinical symptoms of GPT,TBAL and hepatitis were analyzed and analyzed after treatment.Results GPT was（42.3±2.8） U/L in the control group and（38.5±2.6） U/L in the experimental group.The analysis was statistically significant（t=7.03,P〈0.01）.The TBAL was（22.4±3.1） μmol/L in the control group and（18.2±2.7） μmol/L in the experimental group. The analysis was statistically significant（t=7.22,P〈0.01）. The number of patients with jaundice,rib pain,nausea and fatigue was more than that of the experimental group,and the clinical analysis was statistically significant（P〈0.01）. Conclusion Traditional Chinese medicine decoction can effectively prevent liver function in patients with anti-tuberculosis medication,prevent jaundice,rib pain,nausea,fatigue and other clinical symptoms caused by hepatitis.Is conducive to reducing the anti TB drugs on liver damage and maintain the normal application of anti-TB drugs.The treatment is worthy of promotion in clinical practice.

关 键 词：中药汤剂 抗结核药 药物性肝炎 

分 类 号：R259[医药卫生—中西医结合]