吡嗪酰氨硫脲衍生物的合成  

Synthesis of Pyrazine-Carbonyl Thiosemicarbazides

作　　者：王锐[1] 靳立人[1] 吴秀琴[1] 黄玉初 吴春英 王艳君 

机构地区：[1]南京药物研究所,210009 [2]中国药科大学生物中心

出　　处：《中国药科大学学报》1991年第4期233-235,共3页Journal of China Pharmaceutical University

摘　　要：由于近年来性传播疾病的流行,治疗淋病的药物青霉素及壮观霉素先后出现了耐药菌株,因此寻找治疗淋病的有效新药非常必要。1980年Dobck等报道2-乙酰吡啶缩氨硫脲衍生物对淋球菌和金黄色葡萄球菌的抑菌效果。12 Compounds of pyrazine-carbazides were synthesized and characterized. These compounds were screened for their antibacterial properties against Bacillus subtilis 6633, Staphylococcus aureus 209p, Escherichia coli, Pseudomonas aeruginosa and Neisseria gonorrhoeae 29106-3. The results of testing for antibacterial activity revealed that the compounds Ⅷ 1, 2, 4, 7, 8, 9 10, 11, 12 had inhibited the growth of Pseudomonas aeruginosa at concentration of 50—25 μg/ml. Poor or no antibacterial activity was shown toward the other bacterial genera.

关 键 词：吡嗪酰氨硫脲 合成 淋球菌 

分 类 号：TQ463.27[化学工程—制药化工]