透脓散对浅部化脓性炎症趋化因子补体5a、白三烯4的影响  

Effect of Tounong powder on chemotactic factor C5a and LTB4 in superficial purulent inflammation

作　　者：石志强[1] 班秀芬[1] 李元奎[1] 张小平 肖成 

机构地区：[1]内蒙古医科大学,呼和浩特010110 [2]内蒙古自治区中医医院,呼和浩特010020

出　　处：《长春中医药大学学报》2017年第5期703-705,共3页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金项目(81660792);内蒙古自治区自然科学基金资助项目(2014MS0838);内蒙古自治区卫生和计划生育委员会资助项目(201301020)

摘　　要：目的研究透脓散对浅部化脓性炎症血中趋化因子补体5a(C5a)、白三烯4(LTB4)及局部愈合情况的影响,探讨透脓散扶正托毒的作用机理。方法将Wistar大鼠分为病模对照组,透脓散高、中、低剂量组、头孢拉定组,采用金黄色葡萄球菌局部注射致大鼠背部浅部化脓性炎症模型,分别给予相应药物灌胃,观察脓肿大小及愈合情况,于3、6、9 d取血检测C5a、LTB4。结果透脓散可使脓肿缩小,促进脓肿愈合;透脓散6 d小组能降低血C5a水平,9 d小组升高血C5a水平,且与头孢拉定组比较差异显著;透脓散3 d小组明显降低血LTB4水平,6 d小组与9 d小组可升高血LTB4水平,且与头孢拉定组比较差异显著。结论透脓散能使浅部化脓性炎症缩小局限,加快愈合,并且可以影响血C5a、LTB4水平,具有双向调节作用。Objective To explore effect of Tounong powder on C5a, LTB4 and abscess healing in superficial purulent inflammation, and analyse its mechanism. Methods The wistar rats were divided into disease model control group, high, middle and low doses of Tounong powder groups, cefradine group, inject staphylococcus aureus into rat＇s back with superficial purulent inflammation, the different groups rats were treated with different treatment. Observing the size and healing of abscess, taking blood sample to test C5a and LTB4 on the 3,6 and 9-day. Results Tounong powder can reduce the size of abscess and promote the healing of the abscess; 6-day group of theTounong powder can reduce the C5a level, 9-day group of it increased C5a level, and the difference was significant between it and cefradine group; 3-day group of the Tounong powder can reduce the LTB4 level, 6-day group and 9-day group of the Tounong powder can increased the LTB4 level, the difference was significant between it and cefradine group. Conclusion Tounong powder can reduce the size of abscess, promote the healing of the abscess, and affect the blood C5a, LTB4 levels with dual regulation.

关 键 词：透脓散 浅部化脓性炎症 愈合率 C5A LTB4 

分 类 号：R288.5[医药卫生—中药学]