伊伐布雷定在稳定型心绞痛合并慢性阻塞性肺疾病患者中的应用  

Application of Ivabradine in patients with stable angina pectoris complicated with chronic obstructive pulmonary disease

作　　者：李松彪[1] 谭萃妍 

机构地区：[1]中山大学附属第五医院CCU,广东珠海519000

出　　处：《中国当代医药》2017年第28期39-41,共3页China Modern Medicine

摘　　要：目的观察伊伐布雷定在稳定型心绞痛合并慢性阻塞性肺疾病(COPD)中的应用效果。方法选取2014年1月1日~2016年12月30日本院接收的42例稳定型心绞痛合并COPD患者,将其随机分为常规治疗组、伊伐布雷定组,各21例。常规治疗组给予冠心病常规治疗,伊伐布雷定组在对照组基础上联合伊伐布雷定。比较两组的应用效果。结果治疗后,两组的肺功能指标差异无统计学意义(P>0.05);与常规治疗组比较,伊伐布雷定组的6 min步行实验距离、CAT评分均改善,24 h平均心率明显下降,心绞痛发作次数及硝酸甘油使用量均较常规治疗组明显减少(P<0.05)。结论稳定型心绞痛合并COPD患者应用伊伐布雷定,可提高患者运动耐量和生活质量,减少心绞痛发作次数,效果确切,可推荐。Objective To observe the application effect of Ivabradine in patients with stable angina pectoris complicated with chronic obstructive pulmonary disease （COPD）.Methods From January 1,2014 to December 30,2016,42 patients with stable angina pectoris complicated with COPD were selected in our hospital.They were randomly divided into the routine treatment group and ivabradine group,with 21 cases in each group.Routine treatment was used in the former group and ivabradinewas added besides treatment in routine group.The application effect was compared between the two groups.Results After therapy,there was no statistical difference of pulmonary function indexes between the two groups （P〉0.05）.ln the ivabradine group,6-min walking distance and CAT score were both improved.The 24-hour average heart rate was significantly decreased as well as frequency of angina pectoris and doses of Nitroglycerin compared with those in the routine group with statistical differences （P〈0.05）.Conelusion For patients with stable angina pectoris and COPD,Ivabradinecan applied can improve the patients＇ exercise tolerance and quality of life,and reduce the attack times of angina peetoris in a definite effect,which can be recommended.

关 键 词：伊伐布雷定 慢性阻塞性肺疾病 稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]