口服和注射甘草酸二铵对小鼠的免疫功能影响的比较  

Comparison of effects of Oral and parenteral diammonium glycyrrhizinate on some immune function in mice

作　　者：方红英[1] 宋小莉[1] 吴锡铭[2] 

机构地区：[1]浙江大学药学院,杭州310006 [2]杭州市第六人民医院临床药理室,杭州310014

出　　处：《中国现代应用药学》2002年第4期274-275,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :研究口服和注射甘草酸二铵对小鼠血清α INF及碳粒廓清率的影响。方法 :应用细胞病变方法测定小鼠血清α INF含量和分光光度法测定血液碳粒廓清指数K值 ,并进行两组比较。结果 :静脉注射甘草酸二铵能显著提高血清α INF水平 (P <0 .0 5 )及增加碳粒廓清指数K值 (P <0 .0 1) ,并优于口服给药。结论 :IV甘草酸二铵能诱生血清αOBJECTIVE:The effects of oral and parenteral diammonium glycyrrhizate(DGL) on the serum α Interferon(α INF) and the clearance rate of characoal particles in mice were investigted. METHOD:The level of α INF and the clearance rate of charcol particles were determined by the 50% plaque reduction method on L monolayer cell cultures and by the spectrophotometry respectivevely. RESULTS:Increased level of α INFand clearance rate of charcol particles were found by intravenous administration of DGL in mice. These results demonstrated that the iv administration of DGL was supperior to that by orally. CONCLUSION:Intravenous administration of DGL has actions ofα INF inducing and incereasing the clearance rate of charcol particles.

关 键 词：免疫功能 甘草酸二铵 Α-干扰素 碳粒廓清率 

分 类 号：R965.2[医药卫生—药理学]