综合干预对乙肝病毒相关性肝癌TACE患者药物依从性的效果研究  

Effect of comprehensive intervention on the drug compliance in patients with hepatitis B virus-related hepatocellular carcinoma after receiving TACE

作　　者：尤国美[1] 邵国良[1] 杨方英[1] 朱萍[1] 赵谷[1] 曾晖[1] 张锐[1] 毛恋琴 夏黎瑶 

机构地区：[1]浙江省肿瘤医院介入科,杭州310022

出　　处：《介入放射学杂志》2017年第10期931-934,共4页Journal of Interventional Radiology

基　　金：浙江省自然科学基金(LY17H180006);浙江省医药卫生科技计划项目(2014KYB042)

摘　　要：目的探讨由护理人员主导的综合干预对乙肝病毒相关性肝癌TACE患者药物依从性的影响。方法本研究采用随机抽样的方法纳入96例某三级甲等肿瘤医院介入科曾接受TACE治疗并服用核苷酸类似药物1个月的乙肝病毒相关性肝癌患者。患者在知情同意的前提下,接受由护理人员主导的、医师和护士共同实施的综合干预。结果 (1)干预后的服药依从性得分平均值(93.67±6.046)高于干预前(82.04±10.024)(P<0.05),干预后服药依从性良好的患者的比率(97.8%)高于干预前(62.4%)(P<0.05);(2)干预后血清HBVDNA处于正常范围的患者比率(45.16%)高于干预前(15.05%)(P<0.05)。结论由护理人员主导的综合干预能有效改善乙肝病毒相关性肝癌TACE患者药物依从性,有利于控制血清HBVDNA水平。Objective To investigate the effect of comprehensive intervention led by nursing staffers on the drug compliance in patients with hepatitis B virus-related hepatocellular carcinoma （HCC） after receiving transcatheter arterial chemoembolization （TACE） treatment. Methods By using random sampling method, a total of 96 patients with hepatitis B virus-associated HCC, who had been treated with TACE and had taken nucleotide analogue drug for one month in the interventional department of a certain grade m tumor hospital, were enrolled in this study. Under the premise of informed consent, comprehensive intervention, which was led by nursing staffers and was participated by both doctors and nurses, was conducted. Results After comprehensive intervention, the average score of drug compliance was （93.670±6.046） points, while the pre-intervention average score of drug compliance was （82.040±10.024） points, the difference between the two was statistically significant （P〈0.05）. The ratio of patients who showed good drug compliance changed from pre-intervention 62.4% to post-prevention 97.8%（P〈0.05）. The post-prevention of patients, whose hepatitis B virus deoxyribonucleic acid （HBVDNA） level was within the normal range, was 45.16%, which was higher than the pre-intervention ratio of 15.05%, the difference between the two was statistically significant （P〈0.05）. Conclusion The comprehensive intervention led by nursing staffers can effectively improve the drug compliance in patients with hepatitis B virus-associated HCC after receiving TACE, and can reliably control serum HBVDNA level as well.

关 键 词：综合干预 乙肝病毒相关性肝癌 经动脉化疗栓塞治疗 服药依从性 

分 类 号：R473.73[医药卫生—护理学]