盐酸雷尼替丁泡腾颗粒剂的血药浓度的测定及其药物动力学的研究  

Determintion of Ranitidine Hydrochloride Effervescent Granules in Human Plasma By HPLC And Its Pharmacokinetic Studies

作　　者：李会林[1] 高素英[1] 金鸥[1] 殷国真[1] 

机构地区：[1]浙江省药品检验所,杭州310004

出　　处：《中国现代应用药学》2002年第4期312-313,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :测定 10个男性健康者 11个时间点盐酸雷尼替丁泡腾颗粒剂的血药浓度及其药物动力学参数。方法 :10名男性健康志愿者口服盐酸雷尼替丁泡腾颗粒剂 ,采用HPLC法测定人血清中药物浓度并进行其药物动力学的研究。以ALLTIMAC18为固定相 ,0 .0 2mol·L 1磷酸二氢钾溶液 甲醇 (70 :30 )为流动相 ,检测波长为 32 0nm。结果 :泡腾颗粒剂血药浓度曲线均符合二室模型。其主要药物动力学参数 :Tpeak为 (1.96± 0 .5 5 )h ,Cmax为 (6 6 5± 2 13) μg·L 1,AUC为 (345 2± 6 0 1)h·μg·L 1。结论 :结果表明本法提取简便 ,灵敏度高 。OBJECTIVE:To determine serum concentration of ranitidine Hydrochloride Effervescent Granules in 10 normal male at 11 time points. METHOD:A single oral dose of 150mg ranitidine hydrochloride effervescent granules. The concentration in plasma was determined by HPLC. The extract was analyzed subsequently on ALLTIMA C 18 columu with 0.05mol·L 1 potassium dihydrogen phosphate methanol(70:30) as mobile phase, detected at 320 mn. RESULTS:The concentration time curves of rannitidine hydrochloride effervescent granules products fitted to two compartment open model. The main pharmacokinetic parameters were: T peak (1.96±0.55)h C max (665±213)μg·L 1 , AUC(3452±601)h·μg·L 1 .CONCLUSION:This method is simple with high sensitivity and good precision.

关 键 词：盐酸雷尼替丁泡腾颗粒剂 高效液相色谱法 药物动力学 血药浓度 

分 类 号：R975.6[医药卫生—药品]