临床观察缓释异搏定治疗原发性高血压  

Clinical observation about essential hypertensive treatment with Isoptin SR

作　　者：杨苏生[1] 

机构地区：[1]上海市东方医院心内科,上海200120

出　　处：《中国现代应用药学》2002年第4期333-334,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :观察缓释异搏定片治疗原发性高血压临床效果。方法 :将 6 6例原发性高血压患者停用一切降压药物 2周 ,改缓释异搏定片 2 4 0mg晨 8时服用 4周 ,并于用药第一天分别测 2、6、12、2 4h血压 ,心率 ,以后 3d每日一次 ,3d后每周随访 1- 2次 ,测血压 ,心率 ,心律并询问服药后感觉等 ,有无副作用 ,观察 4周 ,了解治疗前后降压疗效。结果 :缓释异搏定片服用 2h后出现降压作用并且有持续性 ,收缩压 /舒张压平均下降了 :37.6 5± 11.34/ 2 5 .4± 8.4mmHg。与治疗前相比差异均有非常显著性 (P <0 .0 0 1) ,总有效率达 97% ,获得满意降压效果。结论 :缓释异搏定片一天一次 ,2 4h平稳降压 ,长期应用疗效依旧 ,服用方便 ,副作用少 。OBJECTIVE:To study clinical effect on antihypertensive treatment with Isoptin SR (verapamil HCI). METHOD:After 2 weeks of stopping all antihypertensive drugs, sixty six patients with essential hypertension were clinically tested using Isoptin SR (240mg qd), given in the morning at 8 A.M. for 4 weeks. Blood pressure and heart rate were measured at 2, 6, 12, 24h within the first day of therapy, respectively. Then, these patients were underwent 1 2 physical examination each week. Arterial pressure , heart rate and rhythm were measured, the patient's response to oral tablets and adverse reaction were obtained.RESULTS:This drug exerts its pharmacologic effects after 2 hours of oral dosing and prolongs antihypertensive effects to about 24 hours. After therapy, the mean SBP and DBP were 37.65±11.34/25.4±8.4mmHg, respectively. There was significantly difference as compared with those before treatment( P <0.001). A total of therapy effects can reach 97%. Isoptin SR had fewer adverse effects. There are a satisfactory therapeutic efficacy. CONCLUSION:Sustained release verapamil reduced the baseline and peak blood pressure up to 24h post dose. It is a safe and effective drug to essential hypertension. Our study indicates that the drug will provide consistent BP control throughout 24 hours. Isoptin SR treat was a good antihypertensive agents once a day dosing.

关 键 词：疗效 安全 高血压 缓释异搏定 治疗 

分 类 号：R544.105[医药卫生—心血管疾病]