子痫前期患者24h尿蛋白定量与妊娠结局的相关性  

Correlation between 24 h urinary protein quantitation and pregnancy outcome in patients with preeclampsia

作　　者：龚洵 杨美桃 刘海意 乔福元[1] 冯玲 邓东锐 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《新乡医学院学报》2017年第9期808-812,共5页Journal of Xinxiang Medical University

基　　金：国家十二五科技支撑计划项目(编号:2014BAI 05B05);中央高校基本科研业务费专项资金资助项目(编号:2017KFYXJJ119;2017KFYXJJ102)

摘　　要：目的探讨24 h尿蛋白定量与子痫前期患者妊娠结局的相关性。方法选择同济医院2014年1月至2016年12月收治的子痫前期孕妇332例,依据24 h尿蛋白定量结果将患者分为微量蛋白尿组46例(24 h尿蛋白定量<0.3 g)、轻度蛋白尿组98例(0.3 g≤24 h尿蛋白定量<2.0 g)、中度蛋白尿组71例(2.0 g≤24 h尿蛋白定量<5.0 g)和重度蛋白尿组117例(24 h尿蛋白定量≥5.0 g),对4组患者的妊娠结局进行比较。结果轻度蛋白尿组、中度蛋白尿组和重度蛋白尿组患者24 h尿蛋白定量及血清肌酐、尿素氮、尿酸水平显著高于微量蛋白尿组(P<0.05),分娩孕周显著短于微量蛋白尿组(P<0.05);中度蛋白尿组患者24 h尿蛋白定量及血清尿素氮、尿酸水平显著高于轻度蛋白尿组(P<0.05),分娩孕周显著短于轻度蛋白尿组(P<0.05),但2组患者血清肌酐水平比较差异无统计学意义(P>0.05);重度蛋白尿组患者24 h尿蛋白定量及血清肌酐、尿素氮、尿酸水平显著高于轻度蛋白尿组(P<0.05),分娩孕周显著短于轻度蛋白尿组(P<0.05);重度蛋白尿组患者24 h尿蛋白定量显著高于中度蛋白尿组(P<0.05),但2组患者分娩孕周及血清肌酐、尿素氮、尿酸水平比较差异均无统计学意义(P>0.05)。4组患者剖宫产率及顺产率比较差异均无统计学意义(P>0.05)。中度蛋白尿组和重度蛋白尿组患者治疗性引产率显著高于轻度蛋白尿组和微量蛋白尿组(P<0.05),但轻度蛋白尿组与微量蛋白尿组患者治疗性引产率比较差异无统计学意义(P>0.05),重度蛋白尿组与中度蛋白尿组患者治疗性引产率比较差异无统计学意义(P>0.05)。微量蛋白尿组、轻度蛋白尿组、中度蛋白尿组和重度蛋白尿组患者并发症发生率分别为30.43%(14/46)、47.96%(47/98)、74.65%(53/71)、74.36%(87/117),中度蛋白尿组和重度蛋白尿组患者并发症发生率显著高于微量蛋白尿组和轻度蛋白尿组(P<0.05),微量蛋白尿组与轻度蛋Objective To investigate the correlation between 24 h urinary protein quantitation and pregnancy outcome in patients with pre-eclampsia.Methods A total of 332 pre-eclampsia patients were selected in Tongji Hospital from January 2014 to December 2016.The patients were divided into microalbuminuria group（24 h urinary protein quantification 〈 0.3 g,n =46）,mild proteinuria group （0.3 g ≤ 24 h urinary protein quantification 〈 2.0 g,n =98）,moderate proteinuria group （2.0 g ≤ 24 h urinary protein quantification 〈 5.0 g,n =71） and severe proteinuria group（24 h urinary protein quantification ≥ 5.0 g,n =117） according to the results of 24 h urinary protein quantification.The pregnancy outcomes were compared between the four groups.Results The 24 h urinary protein quantification and the serum creatinine,urea nitrogen,uric acid levels in the mild proteinuria group,moderate proteinuria group and severe proteinuria group were significantly higher than those in the microalbuminuria group （P 〈 0.05）;and gestational week was significantly shorter than that in the microalbuminuria group （P 〈 0.05）.The 24 h urinary protein quantification and serum urea nitrogen,uric acid levels in the moderate proteinuria group were significantly higher than those in the mild proteinuria group （P 〈 0.05）;and gestational week was significantly shorter than that in the mild proteinuria group （P 〈 0.05）;but there was no significant difference in serum creatinine level between the two groups （P 〉 0.05）.The 24 h urinary protein quantification,serum creatinine,urea nitrogen and uric acid levels in the severe proteinuria group were significantly higher than those in the mild proteinuria group （P 〈 0.05）;and the gestational week was significantly lower than that in the mild albuminuria group （P 〈 0.05）.The 24 h urinary protein quantification in the severe proteinuria group was significantly higher than that in the moderate proteinuria group （P 〈 0.05）,but there was no significant d

关 键 词：子痫前期 尿蛋白 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]