第458例——发热、血细胞减少、腹痛、多发肠道溃疡穿孔  

The 458th case： fever, cytopenia, abdominal pain, and multiple intestinal ulcerations with perforation

作　　者：林艳 谢洪虎[2] 赵伟[3] 吴敏[4] 顾伟英[1] 

机构地区：[1]常州市第一人民医院血液科,江苏常州213003 [2]常州市第一人民医院胃肠外科,江苏常州213003 [3]常州市第一人民医院病理科,江苏常州213003 [4]常州市第一人民医院风湿免疫科,江苏常州213003

出　　处：《中华内科杂志》2017年第10期789-792,共4页Chinese Journal of Internal Medicine

摘　　要：报道1例有20年反复口腔溃疡、外阴溃疡和虹膜炎病史的48岁女性，4年前确诊骨髓增生异常综合征（MDS）合并8号染色体三体，近期出现高热及剧烈的腹痛。外科手术发现肠道多发溃疡，最终诊断MDS合并肠道白塞病，免疫抑制药物治疗后病情缓解。Trisomy 8 in myelodysplastic syndrome （MDS） plays an important role in concurrent intestinal Beh？et′s disease （BD） pathogenesis. Here, we reported a case of intestinal BD combined with MDS involving trisomy 8. A 48-year-old woman who has had a 20-year history of recurrent oral ulcer, perineal ulcer and iris, was diagnosed as MDS with trisomy 8 four years ago. She developed high fever and acute abdominal pain. Multiple ulcerative perforations in ileum and colon were found by endoscopy, meeting the criteria for intestinal BD. The patient was successfully treated with immunomodulatory drugs.

关 键 词：骨髓增生异常综合征 白塞病 

分 类 号：R55[医药卫生—血液循环系统疾病] R597.9[医药卫生—内科学]