葛根素及其衍生物抗炎、抗痛风作用研究进展  

Research progress of puerarin and its derivatives on anti-inflammatory and anti-gout activities

作　　者：邢志华[1] 马誉畅 李新萍 张冰[2] 张梦迪 万升敏 杨鑫 杨天凤 姜婧雯 包然 

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2017年第19期3703-3708,共6页China Journal of Chinese Materia Medica

基　　金：黑龙江省自然科学基金面上项目(H2016001);哈尔滨商业大学博士科研启动项目(92508964);大学生创新创业训练计划项目(201610240001;国家级);2016年教育部中西部高等学校青年骨干教师国内访问学者项目

摘　　要：该文综述了葛根素及其衍生物在抗炎、抗痛风方面的研究进展。葛根素可通过影响免疫细胞、炎性因子、信号通路等方式起到抗炎作用;同时可通过抑制黄嘌呤氧化酶、促进尿酸排泄降低血清尿酸水平,达到抗痛风作用。虽然与临床使用的别嘌醇相比,其体内降尿酸水平活性较低,但葛根素能增强机体总抗氧化和清除氧自由基的能力,且抗炎作用较强,因此预测,以葛根素为先导化合物,对其结构进行修饰或改造以期寻找活性好、副作用小的新型抗痛风药物将是一个有一定前景的研究方向。The research progress of puerarin and its derivatives in anti-inflammatory and anti-gout activities was reviewed in this paper. Puerarin possesses anti-inflammatory activity by affecting immunocyte,inflammation cytokines and signaling pathway. Puerarin also has anti-gout activity through inhibition of xanthine oxidase,promoting the excretion of uric acid to reduce serum uric acid level. Although its ability in reducing uric acid level was lower than that of allopurinol in clinical application,puerarin can also enhance the total antioxidant and free radical scavenging with stronger anti-inflammatory effect,so it will be a promising research direction to find new drugs with better anti-gout activity and less side effects by modifying the chemical structure of puerarin.

关 键 词：葛根素 葛根素衍生物 抗炎 抗痛风 黄嘌呤氧化酶抑制剂 

分 类 号：R285.5[医药卫生—中药学]