盐酸普拉克索缓释片的制备及其释药性的研究  

Preparation of Pramipexole dihydrochloride sustained-release pellet tablets and its release characteristics

作　　者：丁宏伟[1] 戈文兰[2] 张根元[2] 任丽莉[1] 陈国广[1] 

机构地区：[1]南京工业大学药学院,江苏南京211816 [2]江苏省药物研究所,江苏南京210009

出　　处：《华西药学杂志》2017年第5期463-466,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的制备盐酸普拉克索缓释微丸片。方法采用流化床包衣法制备盐酸普勒克索微丸,再将微丸与一定的辅料混合后压制成片。利用正交试验确定了微丸的最终处方。结果最优处方为10%碳酸氢钙用量、3%包衣增重率、25%柠檬酸三乙酯用量。自制缓释微丸片在分割后其释放行为与整片相似。结论自制缓释微丸片与市售缓释片的释放行为相似。OBJECTIVE To prepare Pramipexole dihydrochloride sustained-release pellet tablets. METHODS The Pramipexole dihydrochloride sustained-release pellets were prepared by fluid bed coating technology. Pellets and suitable excipients were mixed,and then compressed to tablets. The orthogonal experiment was used to determine the final prescription. RESULTS The best prescription was selected as： 10% DCP,10% coating weight,3% silica dioxide weight,25% triethyl citrate. The release behavior of the split tablet was consistent with intact tablet. CONCLUSION The release behavior of the developed sustained-release pellet tablets and the marketed sustained-release tablets are consistent.

关 键 词：盐酸普拉克索 缓释微丸 流化床包衣 微丸压片 正交试验 释放度 多单元缓释片 

分 类 号：R94[医药卫生—药剂学]