六味地黄丸对狼疮肾炎患者糖基化终末产物受体、单核细胞趋化蛋白1及趋化因子Fractalkine的影响  

Effect of Liu Wei Di Huang Wan on RAGE,MCP-1 and Fractalkine in blood and urine of patients with lupus nephritis

作　　者：张亚男[1] 

机构地区：[1]大连大学附属中山医院肾内科,大连116001

出　　处：《临床肾脏病杂志》2017年第8期499-502,共4页Journal Of Clinical Nephrology

摘　　要：目的观察六味地黄丸对狼疮肾炎患者糖基化终末产物受体(receptor for advanced glycation end products,RAGE)、单核细胞趋化蛋白1及趋化因子Fractalkine水平的影响,探讨六味地黄丸用于狼疮肾炎的临床疗效,以期为临床上狼疮肾炎的治疗提供参考。方法收集大连大学附属中山医院2014年9月至2016年9月肾内科门诊收治的狼疮肾炎患者46例,其中男性25例,女性21例,按照随机数字表法原则分为观察组和对照组,每组23例,其中对照组给予甲泼尼龙0.5 g/d静脉滴注3 d后口服泼尼松片(0.6 mg·kg^(-1)·d^(-1))治疗,8周后逐渐减量至10 mg/d维持治疗;观察组在常规西医治疗的基础上给予浓缩六味地黄丸辅助治疗,8丸/次,3次/日,均进行8个疗程(16 d为一个疗程)治疗。分别比较2组患者治疗前、后糖基化终末产物受体、单核细胞趋化蛋白1及趋化因子Fractalkine水平以及2组患者的临床疗效进行观察。结果与对照组临床疗效相比,六味地黄丸观察组总有效率为78.3%,高于对照组的70.0%(P<0.05);与对照组治疗后相比,观察组治疗后糖基化终末产物受体、单核细胞趋化蛋白1、趋化因子Fractalkine水平显著低于对照组(P<0.05)。结论六味地黄丸辅助常规西药治疗狼疮肾炎能够降低糖基化终末产物受体、单核细胞趋化蛋白1以及趋化因子Fractalkine的表达,提示六味地黄丸能够通过减轻狼疮肾炎的相关指标对狼疮肾炎具有治疗作用,值得临床进一步推广。Objective To observe the effect of Liuwei Dihuang Wan on the levels of glycated end products receptor（ RAGE）,monocyte chemoattractant protein-1（ MCP-1） and chemokine Fractalkine in patients with lupus nephritis（ LN）,and to explore the curative effectiveness of Liuwei Dihuang Wan for LN.Methods Forty-six patients with LN were enrolled in our hospital from September 2014 to September 2016.Among them,25 males and 21 females were randomly divided into two groups： observation group（ n = 23）and control group（ n = 23）. The control group was intravenously injected with methylprednisolone（ 0. 5 g/day） for 3 days,then prednisone（ 0. 6 mg·kg^-1·day^-1） was administered orally,and 8 weeks later,gradually reduced to 10 mg/day for maintenance treatment. On the basis of routine western medicine treatment,the observation group was given adjuvant treatment of concentrated Liuwei Dihuang Wan,8 pills/time,3times/day for 8 courses（ 16 days for a course）. The levels of RAGE,MCP-1 and chemokine Fractalkine,and the clinical efficacy were observed in two groups before and after treatment. Results The total effective rate in the observation group（ 78. 3%） was significantly higher than that in the control group（ 70. 0%,P〈0. 05）. The RAGE,MCP-1 and Fractalkine levels after treatment were significantly lower in the observation group than in the control group. Conclusions The results showed that Liu Wei Di Huang Wan combined with conventional western medicine can reduce the expression of RAGE,MCP-1 and Fractalkine,exerting its clinical efficacy in the treatment of LN.

关 键 词：狼疮肾炎 六味地黄丸 糖基化终末产物受体 单核细胞趋化蛋白1 

分 类 号：R593.242[医药卫生—内科学]