氧化石墨烯-二氧化钛纳米材料对吲哚菁绿稳定性及体内分布的影响  

Influence of graphene oxide-titanium dioxide nanomaterial on the stability and in vivo distribution of indocyanine green

作　　者：李文武[1] 张晓戈 祝杏 张慧娟[2] 

机构地区：[1]河南省食品药品评价中心,郑州450018 [2]郑州大学药学院药物分析教研室,郑州450001

出　　处：《郑州大学学报（医学版）》2017年第5期567-570,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:研究氧化石墨烯-二氧化钛纳米材料(Ti O2-GO)对吲哚菁绿(ICG)稳定性及体内分布的影响,探讨Ti O2-GO/ICG作为光敏剂应用于肿瘤治疗的可能性。方法:采用紫外-可见吸收光谱法,研究储存时间及激光照射等因素对ICG和Ti O2-GO/ICG稳定性的影响;并以荷瘤小鼠为模型,静脉注射后,利用小动物活体成像仪观察Ti O2-GO对ICG体内分布的影响。结果:Ti O2-GO可以有效增强ICG在常温储存以及近红外激光照射下的稳定性;作为纳米材料,Ti O2-GO可显著改善ICG在体内的分布,增强其在肿瘤部位的蓄积。结论:Ti O2-GO可通过增强ICG稳定性及肿瘤部位蓄积提高其光疗效果。Aim： To investigate the influence of graphene oxide-titanium dioxide nanomaterial（ Ti O2-GO） on the stability and in vivo distribution of indocyanine green（ ICG）. To explore the possibility of Ti O2-GO/ICG used for cancer treatment as a photosensitizer. Methods： UV-Vis absorption spectrum was used to evaluate the impact of storage time and laser irradiation on the stability of ICG and Ti O2-GO/ICG. The effects of Ti O2-GO on in vivo distribution of ICG were observed in4T1 tumor-bearing mice by intravenous injection. Results： The results showed that Ti O2-GO could enhance storage stability of ICG at room temperature and under near-infrared laser irradiation. As a nanomaterial,Ti O2-GO could significantly improve the in vivo distribution of ICG and enhance its accumulation in the tumor. Conclusion： Ti O2-GO can improve the phototherapy effect of ICG by enhancing its stability and tumor accumulation.

关 键 词：吲哚菁绿 氧化石墨烯-二氧化钛纳米材料 紫外-可见吸收光谱 稳定性 体内分布 

分 类 号：R917[医药卫生—药物分析学]