生长因子在关节软骨损伤修复中的应用进展  

Application of growth factor in repair of articular cartilage injury

作　　者：曹一汀[1] 杨文裕 李学敏[1] 张其清[1] 

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室,天津300192

出　　处：《国际生物医学工程杂志》2017年第4期280-285,I0007,共7页International Journal of Biomedical Engineering

基　　金：国家自然科学基金（31271023）;天津市应用基础与前沿技术研究计划（14JCZDJC38200）

摘　　要：关节是人体重要的运动器官，其组织结构特殊，成熟关节软骨组织没有血供，一旦损伤难以自愈。临床上常用的关节软骨损伤修复手段有微骨裂术、关节软骨移植、关节置换术、软骨组织工程等，但这些方法的修复效果都不理想。生长因子是体内组织分泌的一种具有生物活性的物质，可促进细胞生长、增殖、迁移和分化。软骨发育过程中有许多生长因子参与，如成纤维细胞生长因子（FGF）、骨形态发生蛋白（BMP）、胰岛素样生长因子（IGF）等。研究显示，在关节软骨修复过程中加入外源性生长因子可有效促进关节软骨损伤的修复。对目前应用于关节软骨损伤修复研究中的生长因子进行综述，讨论这些生长因子在关节软骨发育及其在关节软骨修复中的作用，分析生长因子在关节软骨修复应用中存在的问题。The joint is an important athletic organ, and has special structure, i.e. no blood supply in the mature articular cartilage. Hence, once articular cartilage is damaged and is difficult to self-repair. Nowadays, there are several clinical methods for articular cartilage injury, such as micro-fracture, transplant of articular cartilage, replacement of articular cartilage and cartilage tissue engineering. But the repairing effects of these methods are unsatisfactory. Growth factors are biologically active substances that are synthesized by cells in vivo and can accelerate cell growth, promote cell proliferation and induce cell migration etc. There are many growth factors participate in the development of cartilage, such as fibroblast growth factor （FGF）, bone morphogenetic protein（BMP）, insulin-like growth factor （IGF） and so on. Some research showed that the addition of exogenous growth factor in articular cartilage repair can effectively promote the repair of articular cartilage injury. In this paper, the main growth factors used for articular cartilage injury repair were reviewed, and the functions of these factors in the development and the repair of articular cartilage were discussed. The problems of growth factors in the application of articular cartilage repair were analyzed.

关 键 词：关节软骨损伤 修复 软骨细胞 生长因子 

分 类 号：R684[医药卫生—骨科学]