乳杆菌活菌制剂联合甲硝唑治疗细菌性阴道炎临床效果分析  

Effect analysis of live lactobacillus preparation combined with metronidazole in the treatment of bacterial vaginosis

作　　者：罗菁[1] 邓晶[1] 应伊丽[1] 张培[1] 潘伟[2] 

机构地区：[1]武汉市第一医院妇产科,武汉430000 [2]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)妇产科,湖北黄石435000

出　　处：《中国性科学》2017年第10期60-62,共3页Chinese Journal of Human Sexuality

基　　金：湖北省黄石市2015年度医药卫生科研立项项目(编号:16)

摘　　要：目的:分析乳杆菌活菌制剂对细菌性阴道炎患者微生态的改变。方法:选取从2015年3月至2016年3月共60例慢性盆腔炎患者,按随机表法分为观察组与对照组,每组30例。对照组采用甲硝锉治疗;观察组在此基础上加服阴道用乳杆菌活菌胶囊(定君生)。观察比较两组临床疗效、治疗后不良反应发生率及复发率,并对治疗前后化验检查结果进行比较。结果:观察组总有效率(96.7%)显著高于对照组(76.7%)(P<0.05),两组治疗后对照组不良反应发生率30.0%显著高于观察组的3.3%;治疗后1个月及3个月的复发率也明显高于观察组(P<0.05);观察组治疗后线索细胞转阴率(90.0%)、胺试验转阴率(92.6%)及p H恢复正常率(93.3%)均略高于对照组,两组化验检查结果无统计学差异(P<0.05)。结论:乳杆菌活菌制剂可有效改善细菌性阴道炎患者微生态,起到显著的抗菌消炎作用。Objectives： To study the effect of live lactobacillus preparation combined with metronidazole in the treatment of bacterial vaginosis. Methods： A total of 60 patients with chronic pelvic inflammatory disease from March 2015 to March 2016 were randomly divided into observation group and control group,with 30 cases in each group. The control group received metronidazole treatment; the observation group received Lactobacillus Capsule（Ding Junsheng） additionally on the basis of control group＇s treatment. The clinical efficacy,adverse reaction rate and recurrence rate after treatment were observed and compared between the two groups. Results： The total efficiency of the observation group（96. 7%） was significantly higher than that of control group（76. 7%）,（ P 0. 05）.The adverse reaction rate of control group after treatment（30. 0%） was significantly higher than that of observation group after treatment（3. 3%）. At 3 months after treatment,the recurrence rate of control group was significantly higher than that of observation group（ P 0. 05）. In the observation group,the clue cell negative rate（90. 0%）,amine test negative rate（92. 6%） and pH 4. 5 cases（93. 3%） were slightly higher than these in control group,with no statistically significant difference（ P 0. 05）. Conclusion： Live lactobacillus preparation combined with metronidazole can effectively improve the micro ecology of patients with bacterial vaginitis,which has significant antibacterial anti-inflammatory effect.

关 键 词：乳杆菌活菌制剂 细菌性阴道炎 微生态 

分 类 号：R711.31[医药卫生—妇产科学]