血液透析患者血清中骨硬化蛋白与腹主动脉钙化程度的相关性分析  

Correlation between serum sclerostin protein and abdominal aortic calcification degree in patients undergoing hemodialysis

作　　者：申磊[1] 高志英[1] 王莉华[1] 高永宁[1] 侯晶晶[1] 王丽丽[1] SHEN Lei GAO Zhi-ying WANG Li-hua et al(Department of Hemodialysis, The Second Hospital of Hebei Medical U- niversity, Shijiazhuang 050000, Chin)

机构地区：[1]河北医科大学第二医院血液透析科,石家庄市050000

出　　处：《临床合理用药杂志》2017年第29期3-4,17,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析血液透析患者血清中骨硬化蛋白与腹主动脉钙化程度的相关性。方法选取医院接受血液透析治疗的患者40例为观察组,选取同期医院接受健康体检者40例为对照组,所有受检者均接受骨硬化蛋白检查,比较2组之间骨硬化蛋白水平,同时分析观察组腹主动脉钙化程度与骨硬化蛋白水平的相关性。结果观察组骨硬化蛋白水平高于对照组,差异有统计学意义(P<0.05);观察组腹主动脉钙化发生率为45.00%(18/40),且主要位于L4水平;而对照组发生率仅为2.50%(1/40),位于L4水平;重度腹主动脉钙化患者的骨硬化蛋白水平显著高于轻度、中度钙化患者,差异有统计学意义(P<0.05),且随着腹主动脉钙化(AAC)积分的不断增加,患者的骨硬化蛋白水平显著提升。结论血液透析患者血清中骨硬化蛋白水平表达与患者血管钙化程度有着显著的相关性,患者骨硬化蛋白水平升高是患者腹主动脉钙化的高危因素。Objective To analyze the correlation between serum sclerostin protein and the degree of abdominal aortic calcification in patients undergoing hemodialysis. Methods 40 cases who had received hemodialysis in our hospital were se- lected as the observation group;another 40 healthy physical examinees in the hospital during the same period were selected as the control group. All subjects underwent sclerosin examination, and the sclerostin levels in the two groups were compared. Meanwhile, the correlation between the degree of calcification and sclerostin level in the observation group were analyzed. Re- suits The sclerostin level in the observation group was higher than that of the control group, and the difference was statistically significant （P 〈 0.05 ） ;the incidence of abdominal aortic calcification was 45.00% （ 18/40 ） in the observation group ,which mainly distributed on the IA;while the incidence of abdominal aortic calcification was 2.50% （1/40 ） in the control group, dis- tributing on IA ; the sclerostin level of patients with severe calcification was shown to be significantly higher than that of patients with mild and moderate calcification,and the difference was statistically significant （P 〈0.05 ）;with the increase of the AAC integral,the level of sclerosin increased significantly. Conclusion For patients undergoing hemodialysis, the serum sclerostin level is significantly correlated with the severity of vascular calcification, and increased sclerostin level is one of the high risk factors attributing abdominal aortic calcification.

关 键 词：血液透析 骨硬化蛋白 腹主动脉钙化 相关性 

分 类 号：R692.5[医药卫生—泌尿科学]