丙戊酸个体化给药研究进展  

Progress in Individualized Drug Administration of Valproic Acid

作　　者：袁磊[1,2] 马慕白 彭麒霖 王晟鑫 周伯庭 

机构地区：[1]中南大学湘雅医院药学部,长沙410008 [2]中南大学医院药学研究所,长沙410008 [3]中南大学药学院,长沙410006

出　　处：《医药导报》2017年第10期1083-1091,共9页Herald of Medicine

基　　金：国家自然科学基金面上项目(81373491)

摘　　要：丙戊酸是临床一线的广谱抗癫药物,但其代谢易受遗传、联合用药等多种因素影响,因此如何更好实施丙戊酸个体化给药,是临床备受关注的问题。群体药动学将经典的药动学原理与群体统计模型结合,定量地考察患者群体中药物浓度的影响因素,可更好表征个体间差异,实现个体化给药。近年来,许多研究报道丙戊酸的群体药动学研究及其在个体化给药中的应用。该文对近年来丙戊酸相关研究进行综述,总结联合用药及基因多态性对丙戊酸代谢的影响,重点阐述群体药动学指导下丙戊酸个体化给药的最新研究进展。Valproic acid is a first-line broad-spectrum antiepileptic drug, however, the pharmacokinetics of valproic acid are affected by many factors, such as heredity, drug combination and so on. So, how to realize the individualized dosing regimen of valproic acid has received much attention. Population pharmacokinetics combines classical pharmacokinetic principles and population statistical models to quantitatively evaluate the influence factor of drug concentration in the patient population. Thus, it can optimize characterization of the differences among individuals. This article reviews the researches about valproic acid in recent years, and summarizes the effect of the factors on the metabolism of valproic acid, such as drug combination and gene polymorphism. Additionally, focus on the latest research progress of individual administration of valproic acid under the guidance of population pharmacokinetics.

关 键 词：丙戊酸 药动学 群体 基因多态性 个体化给药 

分 类 号：R971.6[医药卫生—药品] R742.1[医药卫生—药学]