深圳市5918例呼吸道感染患者9种呼吸道病原体IgM抗体检测分析  

Nine pathogens IgM antibody detection of 5 918 respiratory tract infections in Shenzhen city

作　　者：龚慧 杜冀晖[1] 高灵莉 李一凡[1] 麦丽文[1] 周蓓[1] 王磊[1] 刘厚聪 

机构地区：[1]深圳市南山区人民医院/广东医科大学附属深圳第六医院中心实验室,广东深圳518052

出　　处：《国际检验医学杂志》2017年第19期2657-2659,2662,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81402310);深圳市科技计划资助项目(JCYJ20140411093600199)

摘　　要：目的分析深圳市患者9种呼吸道病原体的感染特点和流行趋势。方法收集该院就诊的具有急性呼吸道感染症状的患者5 918例,采用间接免疫荧光法检测9种呼吸道病原体的IgM抗体,包括嗜肺军团菌1型(LP1)、肺炎支原体(MP)、Q热立克次体(COX)、肺炎衣原体(CPn)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、乙型流感病毒(INFB)、副流感病毒(PIVs),并对结果进行统计学分析。结果 5 918份血清标本中共检出IgM抗体阳性1 376份,总阳性率为23.25%,其中MP阳性率最高(15.19%),其次为INFB(8.11%),其余几种病原体阳性率较低,混合感染阳性率为4.29%。女性患者中MP、INFB和PIVs IgM抗体的阳性率显著高于男性患者(P<0.001)。MP、INFB和PIVs在不同季节中的阳性率不同,其差异具有统计学意义(P<0.001)。0~14岁组MP、ADV和INFB IgM抗体阳性率显著高于>14~60岁组和>60岁(P<0.05)。婴幼儿(0~14岁)患者MP、CPn、ADV、RSV、INFB和PIVs的阳性率与年龄密切相关(P<0.05)。结论引起深圳市人群非典型肺炎的主要呼吸道病原体,以MP和INFB为主,9种病原体具有各自的感染特点和流行趋势。Objective To analyze the infection characteristics and epidemic trend of 9 respiratory pathogens in Shenzhen population.Methods The 5 918 patients with acute respiratory tract infection were collected,indirect immunofluorescence was used to detect the IgM antibody of 9 respiratory pathogens,including legionella pneumophila type 1（LP1）,mycoplasma pneumoniae （MP）,rickettsia Q （COX）,rickettsia and chlamydia pneumoniae （CPn）,adenovirus （ADV）,respiratory syncytial virus （RSV）,influenza A virus （INFA）,influenza B virus （INFB）,parainfluenza virus （PIVs）,the results were analyzed statistically.Results A total of 1376 samples were detected at least one pathogen in 5 918 serum samples,the total positive rate was 23.25%.The positive rate of MP was the highest （15.19%）,followed by the INFB （8.11%）.The positive rates of other pathogens were relatively low.The mixed infection positive rate was 4.29%.The positive rates of MP,INFB and PIVs in women were significantly higher than those in men（P〈0.001）.The positive rates of MP,INFB and PIVs were different in different seasons,the differences were statistically significant（P〈0.001）.The positive rates of MP,ADV and INFB in 0 to 14 years old group were significantly higher than those in〉14 to 60 years old group and 〉60 years old group （P〈0.05）.The positive rates of MP,CPn,ADV,RSV,INFB and PIVs were closely related with age in infant and children （0 to 14 years old） （P〈0.05）.Conclusion The main respiratory pathogens of SARS in Shenzhen city were MP and INFB,the 9 pathogens had their own infection characteristics and epidemic trend.

关 键 词：呼吸道病原体 IGM抗体检测 间接免疫荧光 感染 

分 类 号：R446.6[医药卫生—诊断学] R56[医药卫生—临床医学]