可降解镁基金属的生物相容性研究进展  

Development in Biocompatibility of Biodegradable Magnesium-Based Metals

作　　者：赵颖[1] 曾利兰 梁涛[1,2] 

机构地区：[1]中国科学院深圳先进技术研究院,深圳518055 [2]中国科学院大学,北京100049

出　　处：《金属学报》2017年第10期1181-1196,共16页Acta Metallurgica Sinica

基　　金：国家自然科学基金项目Nos.81572113和51501218;广东省自然科学基金项目No.2014A030310129;深圳基础研究项目Nos.JCYJ20160229195249481;JCYJ20160429185449249和JCYJ20160608153641020;深港创新圈项目No.SGLH-20150213143207910;深圳市孔雀团队项目No.110811003586331~~

摘　　要：镁基金属以其良好的生物相容性、与骨组织匹配的力学性能以及在人体内可降解吸收等特点,成为极具临床应用前景的新型生物可降解植入材料,未来有望替代传统的医用金属材料(如不锈钢、钛合金等)应用于骨科内植入器件、心血管支架等领域。本文综合评述了近年来国内外可降解镁基金属的生物相容性研究进展,从合金化和表面改性2方面对镁基金属的体内外细胞相容性、血液相容性和组织相容性等相关研究进行了介绍,并对镁基金属未来在临床上的应用和发展趋势进行了展望。Magnesium-based metals become novel biodegradable implanting material and present good clinical application prospect due to their good biocompatibility, mechanical properties matching with bone tissue as well as absorbable and biodegradable properties in human body. They are expected to replace traditional medical metals such as stainless steel and titanium alloy in the area of orthopaedics and cardiovascular stent. In this paper, the current research status about the biocompatibility of magnesium based metals both at home and abroad in recent years has been reviewed. In vitro and in vivo cytocompatibility, hemocompatibility and histocompatibility have been mentioned from aspects of alloying and surface modification. The clinical application and development tendencies for magnesium based metals are also proposed.

关 键 词：镁基金属 降解 细胞相容性 血液相容性 组织相容性 

分 类 号：R318.08[医药卫生—生物医学工程]