乙醇胺毒性及职业接触限值研究进展  

Research advance on toxicity and occupational exposure limits of ethanolamine

作　　者：孙川[1] 钱亚玲[1] 徐承敏[1] 

机构地区：[1]浙江省医学科学院卫生学研究所,浙江杭州310013

出　　处：《环境与职业医学》2017年第10期927-932,共6页Journal of Environmental and Occupational Medicine

基　　金：浙江省医学支撑学科劳动卫生学(编号:11-ZC02);浙江省科技计划项目(编号:2015F10033)

摘　　要：乙醇胺(包括单乙醇胺、二乙醇胺和三乙醇胺)是重要的化工原料,广泛应用于多种化工产品中。乙醇胺可通过呼吸道、消化道以及皮肤多种途径侵入人体,并产生危害。动物实验证明,过量乙醇胺对皮肤、黏膜具有刺激性,被机体吸收后,可致肝、肾损伤,但其致癌性、发育毒性尚不明确。在职业接触限值上,已有26个国家/地区(包括中国在内)制定了单乙醇胺的限值,但大部分国家/地区(包括中国)仍未制定二乙醇胺和三乙醇胺的限值。同时,由于缺乏相关的职业卫生学和职业流行病学调查资料,实际作业环境中乙醇胺暴露对工人健康的影响仍然不明确,现有限值的适用性仍有待评估。Ethanolamine（including monoethanolamine, diethanolamine, and triethanolamine） as an important raw material in chemical industry is widely applied in chemical products. It can affect human health by invading through respiratory tract, digestive tract, and skin. Animal studies have demonstrated that ethanolamine is irritating to skin and mucosa, hepatoxic, and nephrotoxic, but its effects on carcinogenesis and reproductive system are still controversial. Twenty-six countries/regions, including China, have set occupational exposure limits of monoethanolamine, but the limits of diethanolamine and triethanolamine are still absent in most countries/regions, including China. Due to the lack of occupational hygiene and occupational epidemiological studies to elucidate the impact of ethanolamine exposure on worker＇s health in actual occupational settings, the applicability of existed exposure limits remains to be assessed.

关 键 词：乙醇胺 毒性 遗传毒性 致癌性 接触限值 

分 类 号：R135[医药卫生—劳动卫生]