基质金属蛋白酶在紫外线诱导皮肤损伤机制中的研究进展  

Research progress about mechanism of matrix metalloproteinases in the skin damage induced by UV

作　　者：蒋晓霞[1] 李娜[1] 孙震[1] 

机构地区：[1]张家港市疾病预防控制中心,江苏张家港215600

出　　处：《皮肤病与性病》2017年第5期335-338,共4页Dermatology and Venereology

基　　金：张家港市科技支持项目(社会发展)项目编号zks1521

摘　　要：紫外线对人体皮肤的影响较大,已有的研究表明基质金属蛋白酶(MMP)在紫外线诱导的皮肤损伤中扮演着重要角色,其基因启动子的多态性能影响其表达水平,MMP-1、2、3、7、9在紫外线诱导下表达均有不同变化,从而导致皮肤光老化,这种现象与MMP基因的启动子有无关系目前还不清楚。而探索发现多种天然植物提取物能通过MMP对抗紫外线导致的皮肤光损伤,为探索预防和治疗皮肤光老化提供了重要依据。本文对一些已有研究的MMP略作一些综述。Ultraviolet radiation （UV） has a greater influence on human skin, the previous studies have indicated that matrix metalloproteinases （MMPs） play an important role in UV induced skin damage, the polymorphism of the gene promoter affects the expression level; and the expression of MMP- 1, 2, 3, 7, 9 expression were induced with UV, which may lead to skin aging. However, till now it is not clear whether this phenomenon is related to the promoter of the MMP gene. The discovery of a variety of natural plant extracts can be through the MMP against UV induced skin damage, it provides an important ba- sis for the prevention and treatment of skin photo aging. This paper reviews some existing research of MMP.

关 键 词：基质金属蛋白酶 MMP 紫外线 光老化 

分 类 号：R751.02[医药卫生—皮肤病学与性病学] R322.99[医药卫生—临床医学]