丰富环境刺激对小鼠脑认知储备影响的定量研究  

Quantitative study on effect of enriched environmental stimulation on mouse brain cognitive reserve

作　　者：田苗[1] 林岚[1] 王婧璇 吴水才[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《医疗卫生装备》2017年第9期99-104,共6页Chinese Medical Equipment Journal

基　　金：国家科技支撑计划课题(2015BAI02B03);国家自然科学基金(71661167001)

摘　　要：目的:研究丰富环境刺激对小鼠脑认知储备的影响,以改进大脑年龄估值差(brain age gap estimation,Brain AGE)敏感度较低的问题。方法:采用21只清洁级健康成年C57BL/6J雄性小鼠(15月龄),并基于标准环境组、丰富环境组一、丰富环境组二的磁共振显微成像(magnetic resonance microcopy,MRM),运用尺度子配置模型(scaled subprofile model,SSM)对组间最能反映认知储备变化的特征进行分析。结果:丰富环境组和标准环境组的平均Brain AGE在刺激开始后始终存在显著差异。验证了基于Brain AGE预测认知储备的一些假设,经优化后的Brain AGE预测模型可以解释丰富环境刺激时间中58.9%的差异。结论:改善后的Brain AGE测量模型对测量认知储备的余度具有敏感性,可以较好地预测认知储备的余度。Objective To explore the effect of enriched environmental stimulation on mouse brain cognitive reserve to enhance the sensitivity of brain age gap estimation（Brain AGE）. Methods Twenty-one healthy adult C57BL/6J male mice,15 months old, were divided into a group with a standard environment and two groups with enriched environments. All the groups underwent magnetic resonance microcopy. Scaled subprofile model was used to analyze the features reflecting the changes of brain cognitive reserve. Results There were significant differences between the mean Brain AGE of the two groups with enriched environments and that of the remained standard environment group, then it＇s proved that some assumption might be reasonable that brain cognitive reserve could be estimated based on Brain AGE. Optimized Brain AGE model made explanations for 58.9% differences during stimulus phase in enriched environment. Conclusion Improved Brain AGE model gains high sensitivity when used to measure the redundancy of brain cognitive reserve.

关 键 词：认知储备 丰富环境 阿尔茨海默病 大脑年龄估值差 磁共振显微成像 尺度子配置模型 

分 类 号：R338[医药卫生—人体生理学]