奥美拉唑单用或联合法莫替丁治疗胃-食管反流病疗效比较  

Comparative Effect of Omeprazole Alone or Omeprazole Combined with Famotidine in Treating Gastroesophageal Reflux Disease

作　　者：杨晓玉 

机构地区：[1]四川省遂宁市中心医院,四川遂宁629000

出　　处：《中国药业》2017年第19期65-67,共3页China Pharmaceuticals

摘　　要：目的探讨奥美拉唑联合法莫替丁与单用奥美拉唑治疗胃-食管反流病的临床疗效。方法选取医院2014年12月至2016年12月收治的胃-食管反流病患者98例,按就诊编号并依据随机数字抽取表法分为两组,各49例。对照组单用奥美拉唑治疗,观察组应用奥美拉唑联合法莫替丁治疗。结果观察组总有效率为95.92%,显著高于对照组的77.55%(P<0.05);治疗后,两组患者各项症状评分均明显降低,且观察组比对照组降低程度更明显(P<0.05);观察组患者皮疹、便秘、腹痛、口干、恶心等不良反应发生率为10.20%,对照组为12.24%,两组无明显差异(P>0.05);随访半年,观察组复发率为6.12%,对照组为10.20%,两组无明显差异(P>0.05)。结论奥美拉唑联合法莫替丁治疗胃-食管反流病较单用奥美拉唑治疗效果更好,可减轻患者的不良症状,控制不良反应发生率,降低复发率,安全性较高,值得临床推广。Objective To compare the clinical effect of omeprazole alone or omeprazole combined with famotidine in treating gastroe-sophageal reflux disease. Methods Totally 98 patients with gastroesophageal reflux disease admitted to our hospital from December 2014 to December 2016 were randomly selected and divided into two groups according to the medical record number and the random number extraction table, 49 cases in each group. The control group was given omeprazole, while the observation group was given omeprazole combined with famotidine. Results The total effective rate of the observation group was 95. 92%, which was significantly higher than 77. 55% of the control group （ P 〈 0. 05 ） . After treatment, the scores of all symptoms in the two groups were significantly lower than before treatment, and the observation group was significantly lower than the control group （ P 〈 0. 05 ） . The incidence rate of adverse re-actions such as rash, constipation, abdominal pain, dry mouth and nausea in the observation group was not significantly different from that in the control group （ 10. 20% vs. 12. 24%, P 〉 0. 05 ） , and the recurrence rate in the observation group was not significantly dif-ferent from that in the control group during the follow-up period of 6 months （ 6. 12% vs. 10. 20%, P 〉 0. 05 ） . Conclusion Omepra-zole combined with famotidine in treating gastroesophageal reflux disease has better effect than omeprazole alone, it can alleviate the bad symptoms of patients, control adverse reactions and recurrence, which has high safety and worthy of promotion.

关 键 词：奥美拉唑 法莫替丁 胃-食管反流病 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R975.2[医药卫生—药学]