胚胎早期心管发育过程中的信号调控  

The signal regulation of heart tube development in early embryo

作　　者：张静[1] 张萍[1] 梁健欣[2] 李柯 程欣[1] 杨雪松[1] 王广[1,2] 

机构地区：[1]暨南大学医学院组织与胚胎学系,广东广州510632 [2]暨南大学中西医结合研究所,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2017年第5期393-398,共6页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(81571436;31401230);广东省科技计划项目(2014A020213008;2014A020221091);广州市科技计划项目(201510010073)

摘　　要：心脏发生是脊椎动物器官发生中的最早进程之一,其重要功能是为机体提供营养和氧气.心管作为最初心脏的功能承载体和心脏的原基,起着至关重要的作用.心管发育过程受多种信号通路的严密调控,研究证实Wnt信号、Notch信号、BMP信号、FGF信号等均参与心管发育的有关过程,介绍动物胚胎早期心管发育过程中的相关信号传导调控机制的研究现状及进展.The cardiogenesis is one of the earliest processes in vertebrate organogenesis. The function of heart is to provide nutrients and oxygen for the body. Heart tube,which is the initial functional carrier of the heart,plays a vital role in the embryonic development. The developmen of heart tube is regulated by many kinds of signal pathways such as Wnt signal,Notch signal,BMP signal,FGF signal and etc.This review,we focus on the research process of these signal regulations of heart tube development in recent years.

关 键 词：胚胎发育 心管发育 WNT信号 NOTCH信号 BMP信号 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]