重症手足口病细胞免疫变化与病情相关性研究  

Study on the relationship between the changes of cellular immunity and the severity of severe hand foot mouth disease

作　　者：刘婷婷[1] 李文莲[1] 李文菊[1] 陈寿珊 

机构地区：[1]遵义市第一人民医院儿童重症医学科,贵州遵义563000

出　　处：《吉林医学》2017年第10期1881-1883,共3页Jilin Medical Journal

基　　金：贵州省遵义市联合基金项目[项目编号:遵市科合社字(2015)10号]

摘　　要：目的:探讨肠道病毒71型(EV71)与肺炎支原体混合感染致手足口病患儿细胞免疫与病情的相关性。方法:选取重症手足口病患儿160例为研究对象,分为甲组(41例)、乙组(44例)、丙组(38例)、丁组(37例);选取同期40例健康患儿为对照组,各组检测血CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+的不同表达水平,比较四组手足口病危重型发病率。结果:(1)四组手足口病与对照组比较,CD_3^+、CD_4^+及CD_4^+/CD_8^+比值明显降低,手足口病各组比较,丁组至甲组依次降低;差异有统计学意义(P<0.05)。(2)CD_8^+明显增高,丁组至甲组依次升高,差异有统计学意义(P<0.05);(3)危重型发病率甲组最高,丁组最低,差异有统计学意义(P<0.05);(4)乙、丙两组比较,危重型发病率差异无统计学意义(P>0.05)。结论:手足口病EV71病毒与肺炎支原体混合感染者细胞免疫极度异常,更易发展为危重型。Objective To investigate the relationship between cellular immunity and disease in children with hand,foot and mouth disease caused by mixed infection of enterovirus 71 and Mycoplasma pneumoniae. Method 160 cases of severe hand,foot and mouth disease were selected as the research object,the patients were divided into group A 41 cases; 44 cases in group B; 38 cases in group C; D group 37 cases; 40 healthy children were selected as the control group,the levels of CD_3~＋,CD_4~＋ CD_8~＋,CD_4~＋/CD_8~＋ were detected in each group,and the incidence of severe complications of hand,foot and mouth disease was compared. Results（1） the CD_3~＋,CD_4~＋ and CD_4~＋/CD_8~＋ ratios of the 4 groups of hand,foot and mouth disease were significantly lower than those of the control group,4 groups of hand foot and mouth disease were compared,D group to A group in turn lower,the difference was statistically significant（ P〈 0. 05）;（2） The CD_8~＋ was significantly higher in group D to group a gradually increased,the difference was statistically significant（ P〈 0. 05）;（3） The highest incidence of severe group A,group D the lowest,the difference was statistically significant（ P〈 0. 05）;（4） There was no significant difference between the two groups in the incidence of severe acute respiratory syndrome（ P〉 0. 05）. Conclusion Hand foot mouth disease EV71 virus and Mycoplasma pneumoniae mixed infection in patients with abnormal cellular immunity,more likely to develop severe.

关 键 词：重症手足口病 EV71病毒 肺炎支原体 细胞免疫 

分 类 号：R725.1[医药卫生—儿科]