氯维地平杂质的合成  

Synthesis of Impurities of Clevidipine Butyrate

作　　者：史宏亮 王少芃 陈沁文[1] 马文娇[1] 雷萌[1] 

机构地区：[1]南京林业大学理学院,江苏南京210037

出　　处：《化工时刊》2017年第9期14-17,共4页Chemical Industry Times

基　　金：江苏省大学生科研创新项目:201510298106X

摘　　要：分别以3-羟基丙腈和甲醇为原料合成氯维地平的两个杂质CLP-D和CLP-E,并经核磁共振氢谱、核磁共振碳谱和质谱确证其结构。两种杂质的总收率分别是12.80%和12.91%。该合成路线有利于氯维地平的质量控制。Two impurities of clevidipine butyrate CLP-D and CLP-E were synthesized from 3-hydroxypropionitrile and methanol and the structures of the two impurities were confirmed by1 H-NMR,13 C-NMR and Mass Spectrometry（ MS）. The yields were 12. 80% and 12. 91% respectively. The synthetic method could be helpful for the quality control of clevidipine butyrate.

关 键 词：氯维地平 杂质 化学合成 结构表征 

分 类 号：TQ460.1[化学工程—制药化工]