糖尿病痛性神经病变的中枢神经系统影像学研究进展  

Advances in imaging research of the central nervous system in painful diabetic neuropathy

作　　者：张青[1] 吴锦丹[1] 姚志剑[2] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)内分泌科,南京医学硕士研究生210006 [2]南京医科大学附属脑科医院抑郁症专科,南京210029

出　　处：《医学研究生学报》2017年第10期1116-1120,共5页Journal of Medical Postgraduates

基　　金：南京市科技发展计划项目(201605027)

摘　　要：糖尿病痛性神经病变(PDN)严重影响患者的生活质量,而确切的发病机制尚不明确,越来越多的证据显示其中枢神经系统有病理改变。多模态磁共振成像技术能无创地检测中枢神经系统结构及功能的变化,而成为研究该病中枢机制的新手段。文章就PDN的中枢机制及利用多模态磁共振成像技术发现PDN患者存在的丘脑神经功能障碍、丘脑血流增加、躯体感觉皮质周围灰质体积减少以及大脑默认网络、注意网络功能破坏等中枢神经系统改变进行综述。Painful diabetic neuropathy （PDN） seriously affects the patients′life quality, while the exact pathogenesis is un-known.Increasing number of evidences show that these patients have pathological changes of the central nervous system .Multimodal magnetic resonance imaging can noninvasively detect changes in the structure and function of the central nervous system , and become a new means to study the disease mechanisms .This article reviews the central mechanisms of PDN as well as multimodal magnetic reso -nance imaging findings that patients with PDN exist thalamic nerve dysfunction , increased thalamic blood flow , volume reduction of so-matosensory cortical gray matter , the default network and attention network destruction , and so on .

关 键 词：糖尿病痛性神经病变 中枢神经系统 多模态磁共振 

分 类 号：R587.1[医药卫生—内分泌]