二丁颗粒的水提醇沉工艺研究  

Water Extract-alcohol Precipitation Process of Dibutyl Particles

作　　者：张石宇 宋信莉[2] 刘文[2] 汤瑾[1] 石洪州 

机构地区：[1]贵阳中医学院第一附属医院,贵州贵阳550002 [2]贵阳中医学院,贵州贵阳550002

出　　处：《安徽农业科学》2017年第29期3-5,9,共4页Journal of Anhui Agricultural Sciences

摘　　要：[目的]通过水提醇沉法的正交试验优化中药复方制剂二丁颗粒的制备工艺。[方法]采用药典中的水煎煮法制备中药液,采用醇沉法进行精制,以秦皮乙素的含量和出膏率为评价指标,通过正交试验对浓缩浓度、乙醇浓度、静置时间3个因素进行优化。[结果]影响精制结果的因素为浓缩浓度和乙醇浓度,由于静置时间没有显著差异,又从降低成本及节省时间等方面综合考虑,确定最佳工艺条件为:浸膏浓缩浓度为2 g/m L,乙醇浓度为80%,静置时间为18 h。[结论]试验结果为二丁颗粒的剂型改良提供了理论依据。[Objective] The water extract-alcohol precipitation process of dibutyl particles were optimized by orthogonal test. [Method] The pharmacopeia water decoction prepared in solution and alcohol sinking method were adopted to improve the refined. Taking content and extract rate of phenanthrene as the evaluation index,the concentrated sulfate,ethanol concentration and incubation time of alcohol sinking method were optimized by orthogonal test. [Result] The influencing factors of refining the results were enrichment concentration and ethanol concentration.Because there was no significant difference between incubation time,considering cost and save time,the best process conditions were as followed： the extract concentration was 2 g/m L,the ethanol concentration was 80%,and the incubation time was 18 hours. [Conclusion]The results provide reference for 2 d particles reform.

关 键 词：秦皮乙素 水提醇沉法 正交试验 高效液相色谱法 

分 类 号：S-3[农业科学]