济南市878例1～14岁儿童血清乙肝表面抗体定量测定水平分析  

Serum Anti-HBs Levels in 878 Children Aged From 1 to 14 Years Old in Ji'nan City

作　　者：朱效茹[1] 历建芝[1] 于风岭[1] 蒋芙蓉[1] ZHU Xiaoru LI Jianzhi YU Fengling JIANG Furong(Department of Clinical Laboratory, Ji ＇nan Children ＇s Hospital, Ji ＇nan Shandong 250000, Chin)

机构地区：[1]济南市儿童医院检验科,山东济南250000

出　　处：《中国继续医学教育》2017年第23期50-51,共2页China Continuing Medical Education

摘　　要：目的了解济南市1~14岁儿童血清乙肝表面抗体(Anti-HBs)水平,为进行儿童Anti-HBs水平监测及加强免疫决策提供依据。方法选取2014年5月—2017年3月在济南市儿童医院健康查体的1~14岁儿童878例作为研究对象。抽取所有儿童的静脉血,采用化学发光法检测血清Anti-HBs水平。结果 878例1~14岁儿童血清Anti-HBs阳性有639例,阳性率为72.78%。其中,10~100 mIU/ml有252例(28.70%),大于100 mIU/ml有387例(44.08%)。女童血清Anti-HBs阳性率为78.24%(284/363),男童的阳性率为68.93%(355/515),差异具有统计学意义(χ~2=9.31,P=0.002)。不同年龄组间儿童血清HBs-Ab阳性率不同,差异具有统计学意义(χ~2=56.27,P<0.001)。其中1~2岁儿童Anti-HBs阳性率最高,而后逐渐降低,至6~7岁儿童Anti-HBs阳性率最低,而7~10岁儿童Anti-HBs阳性率又呈上升趋势。结论儿童接种乙肝疫苗后随着年龄的增长HBs-Ab阳性率逐渐下降,建议加强儿童乙肝表面抗体的免疫监测,以便及时加强免疫。Objective To investigate the level of Anti-HBs of children aged from 1 to 14 years old in Ji＇nan City, and provide evidence for monitoring the Anti-HBs levels and formulating the strategies for booster immunization. Methods A total of 878 children aged 1-14 years from May 2014 to March 2017 in Ji＇nan children＇s hospital were selected as the study subjects. Venous blood samples were taken from all children and serum Anti-HBs levels were detected by chemiluminescence method. Results 878 cases of 1-14 years old children serum Anti-HBs positive in 639 cases, the positive rate was 72.78%. Among them, 10-100 mIU/ml had 252 cases （28.70%）, there were 387 cases （44.08%） greater than 100 mIU/ml. The positive rate of serum Anti-HBs in girls was 78.24% （284/363）, the positive rate of boys was 68.93% （355/515）, the difference was statistically significant （x^2=9.31, P=-0.002）. The positive rates of serum HBs-Ab in children of different age groups were different, the difference was statistically significant （x^22=56.27, P 〈 0.001）. The positive rate of Anti-HBs in children aged 1-2 years was the highest, and then decreased gradually. The lowest positive rate of Anti- HBs in children aged 6-7 years old. However, the positive rate of Anti-HBs in children aged 7-10 years was on the rise. Conclusion The positive rate of serum anti-HBs was decreased in children with the increase of age after basic vaccination. It is suggested that monitoring of the anti-HBs levels should be strengthened for the implementation of supplementary HBV vaccination.

关 键 词：儿童 乙肝表面抗体 定量检测 化学发光 

分 类 号：R181[医药卫生—流行病学]