两种剂量的7-甲异炔诺酮对60例绝经后妇女症状控制的比较  

A Comparison of Two Kinds o Dosage of OrgOD14 on Controlling of Menopausal Symptoms in 60 Cases Menopausal Women

作　　者：吴洁[1] 姜允飞[1] 周重宛[1] 

机构地区：[1]南京市鼓楼医院妇产科,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2002年第5期415-417,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨两种剂量的7-甲异炔诺酮(OrgOD14,利维爱)对绝经症状控制的比较。方法:60例绝经后妇女随机分为两组:①A组30例,每日口服7-甲异炔诺酮2.5mg。②B组30例,隔日口服7-甲异炔诺酮2.5mg,共6个月。观察服药前后的Kupperman评分变化及血雌二醇、促卵泡激素水平的改变。结果:两组服药后绝经症状明显改善,Kupperman评分明显降低(P<0.01),雌二醇水平显著上升(P<0.01),促卵泡激素水平明显下降(P<0.05),而两组之间差异无显著性。结论:7-甲异炔诺酮可有效地控制绝经症状,每日口服2.5mg并不比隔日口服2.5mg有较好的控制效果(除控制失眠外),故推荐隔日口服2.5mg7-甲异炔诺酮。Objective:To study the effects of two kinds of dosage of OrgOD14 in control of menopausal symptoms.Methods:Sixty patients were divided into 2 groups: 30 patients (group A) were given OrgOD14 2.5mg every day and 30 patients(group B)were given OrgOD14 2.5mg every two days for 6 months.Kupperman Score,the serum FSH and E2 of all patients before and after administration were evaluated.Results:The menopausal symptoms significantly alleviated, Kupperman Score significantly decreased (P< 0.01), the serum E2 significantly elevated (P< 0.01) and the serum FSH significantly lowered (P< 0.05) in both groups after administration of OrgOD14.But there was no significant difference between the two groups.Conclusion:OrgOD14 may effectively control menopausal symptoms.OrgOD14 2.5mg every day does not better control the symptoms than OrgOD14 2.5mg every two days(excluding control of insomnia),which suggests that OrgOD14 2.5mg every two days is enough to alleviate menopausal symptoms.

关 键 词：绝经症状 异炔诺酮 性激素补充治疗 

分 类 号：R711.51[医药卫生—妇产科学]