N,S-配体协助下钯催化的Suzuki-Miyaura交叉偶联反应  

Palladium-Catalyzed Suzuki-Miyaura Cross Coupling Using N,S-Hydrazone as Ligand

作　　者：张占金 田瑜 黄修鹏 屈苗 梁群 陈会英 LIANG Qun CHEN Hui - ying(School of Life Science, Dalian Minzu University, Dalian Liaoning 116605, China)

机构地区：[1]大连民族大学生命科学学院,辽宁大连116605

出　　处：《大连民族大学学报》2017年第5期433-437,共5页Journal of Dalian Minzu University

摘　　要：以廉价、易得的芳(杂环)甲醛、取代肼及羟胺等为原料,合成了9种N,N-、N,O-、N,S-腙及肟配体,并在相对温和的反应条件下,将其应用到了钯催化的Suzuki-Miyaura交叉偶联反应中,开发了一种温和、高效的以腙为配体的钯催化系统Pd(OAc)2/2-噻吩甲醛苯腙(4b)/K3PO4/DMSO。将该系统用于催化苯硼酸与芳溴的交叉偶联反应中,得到了良好的分离收率。Nine N,N-,N,O-,N,S-ligands of hydrazone and oxime were synthesized through inexpensive and available aryl（heterocyclic） formaldehyde,substitutional hydrazine and azanol. The ligands were applied to Suzuki-Miyaura coupling catalyzed by palladium under moderate reaction conditions. A mild and highly efficient palladium-catalyzed system Pd（OAc）2/2-thiophene formaldehyde hydrazone（4b）/K3PO4/DMSO for cross coupling reaction of aryl boric acid with aryl halides using hydrazone as ligand was developed and the good yields were obtained.

关 键 词：芳(杂环)甲醛 腙配体 苯硼酸 芳基溴 Suzuki-Miyaura交叉偶联反应 

分 类 号：O625.41[理学—有机化学]