不同浓度臭氧化自血疗法治疗类风湿关节炎临床研究  

Clinical Research on Different Concentrations of Ozonized Blood Therapy in Treatment of Rheumatoid Arthritis

作　　者：李颖波 蔡毅[1] 蔡少康 吴群[1] 

机构地区：[1]华中科技大学附属武汉市中心医院,湖北武汉430014

出　　处：《湖北中医药大学学报》2017年第5期30-34,共5页Journal of Hubei University of Chinese Medicine

基　　金：武汉市卫生局临床医学科研重点项目(项目编号:WX12B22)

摘　　要：目的观察臭氧自血疗法治疗类风湿性关节炎的临床疗效。方法将80例患者随机分成四组,每组20例,甲氨蝶呤组采用甲氨蝶呤治疗,低浓度臭氧组采用30 g/m L浓度臭氧治疗,中浓度臭氧组采用40 g/m L浓度臭氧治疗,高浓度臭氧组采用50 g/m L浓度治疗,观察治疗前、治疗2周、治疗4周及随访2周后,临床症状评分、VAS评分得分变化;观察治疗前后血沉(ESR)、类风湿因子(RA)、C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-(TNF-)含量及其差值变化。结果与甲氨蝶呤组治疗比较,低、中、高浓度臭氧组不同时点症状得分差异有统计学意义(P<0.05),其中,中浓度臭氧组有显著统计学意义(P<0.01);与甲氨蝶呤组比较,低、中、高浓度臭氧组患者治疗前后ESR,RA得分差值有统计学意义(P<0.05),中、高浓度臭氧组与高浓度臭氧组比较,差异有统计学意义(P<0.05),低、中浓度臭氧组两组比较,差异无明显统计学意义(P>0.05)。结论臭氧自血疗法治疗类风湿性关节炎具有较好的疗效,且安全性较高,值得临床推广使用。Objective To observe the clinical efficacy of ozone auto-blood therapy on rheumatoid arthritis （RA）.Methods 80 cases of patients with RA were randomized into 4 groups, 20 cases in each group. Group A was intervened by acupuncture, Group B was intervened by Ozone 30μg/mL, Group C was intervened by Ozone 401ag/mL, while Group D was Ozone 50μg/ mL, the changes of clinical symptom score, VAS score during the first 2-week, the follow-up, before and after treatment were observed, the levels of ESR, RA, CRP before and after the trial were observed. Results The scores of clinical symptom of Group B, Group D comparing with Group A were different （P〈0.05）, while Group C was significantly different （P〈0.01）;the changes of ESR, RA were not significantly different （P〈0.05）; the changes of Group B, Group C compared with Group D were significantly different （P〈0.05）, the changes of Group B and Group C was not significantly different （P〉0.05）. Conclusion The treatment of RA with oxygen free blood therapy has better efficacy and higher safety, and is worthy of clinical application.

关 键 词：类风湿性关节炎 臭氧自血疗法 随机对照试验 

分 类 号：R259[医药卫生—中西医结合]