复方酮康唑凝胶的制备  

The Preparation of Compound Ketoconazole Gel

作　　者：周进[1] 黄文涛[1] 

机构地区：[1]武汉市中西医结合医院,湖北武汉430022

出　　处：《湖北中医药大学学报》2017年第5期47-50,共4页Journal of Hubei University of Chinese Medicine

基　　金：武汉市卫生局课题(项目编号:WX13D01)

摘　　要：目的制备复方酮康唑凝胶剂。方法通过正交试验设计和溶解扩散模型,筛选出最佳基质配比。结果当凝胶基质配比为卡波姆-940 0.5%、羟丙基--环糊精17.5%、甘油20%、聚乙二醇400 10%时,凝胶中酮康唑和硝酸咪康唑的单位面积累计渗透量均值同为最大值。结论采用优化制备的复方酮康唑凝胶剂外观透明,均匀细腻,粘附性与稳定性良好。Objective To prepare compound ketoconazole gel. Methods Orthogonal experimental design and solution- diffusion model were adopted to select the best substrate compositions. Results When the gel ratio of 0.5% carbopol -940, 17.5% hydroxypropyl-β- cyclodextrin, 20% glycerol, 10% polyethylene glycol 400, the mean value of cumulative permeability per unit area of ketoconazole and miconazole nitrate was the same as the maximum. Conclusion The optimized preparation of compound ketoconazole gel is transparent, uniform and delicate, with good adhesion and stability.

关 键 词：酮康唑 硝酸咪康唑 凝胶剂 羟丙基-B-环糊精 卡波姆-940 

分 类 号：R943[医药卫生—药剂学]